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Rabbit Polyclonal PDIK1L Antibody

  • 中文名: PDIK1L抗体
  • 别    名: CLIK1L; Serine/threonine-protein kinase PDIK1L; PDLIM1-interacting kinase 1-like
货号: IPDX43709
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCLIK1L; Serine/threonine-protein kinase PDIK1L; PDLIM1-interacting kinase 1-like
Entrez GeneID149420;
WB Predicted band size39kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenKLH-conjugated synthetic peptide encompassing a sequence within the center region of human PDIK1L.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PDIK1L抗体的3篇参考文献的简要概括(注:文献为模拟示例,实际文献需通过学术数据库检索确认):

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1. **文献名称**: *PDIK1L regulates cell cycle progression through phosphorylation of cyclin-dependent kinases*

**作者**: Zhang Y, et al.

**摘要**: 本研究利用PDIK1L特异性抗体,通过免疫沉淀和质谱分析,揭示了PDIK1L作为激酶调控CDK1/2磷酸化,从而影响G2/M期转换的分子机制。

2. **文献名称**: *Development and validation of a high-affinity monoclonal antibody for PDIK1L detection in clinical samples*

**作者**: Tanaka K, et al.

**摘要**: 研究团队开发了一种针对PDIK1L C端表位的单克隆抗体,验证了其在Western blot、免疫组化中的特异性,并应用于肺癌组织样本中PDIK1L过表达的病理分析。

3. **文献名称**: *PDIK1L interacts with 14-3-3 proteins to modulate apoptosis in colorectal cancer*

**作者**: Müller S, et al.

**摘要**: 通过免疫共沉淀(使用PDIK1L抗体)和功能实验,证明PDIK1L与14-3-3蛋白结合,抑制线粒体凋亡通路,促进结直肠癌细胞耐药性。

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**备注**:实际研究中建议通过PubMed、Google Scholar等平台,以“PDIK1L antibody”或“PDIK1L kinase”为关键词检索最新文献,部分研究可能涉及抗体在疾病标志物筛选或药物靶点验证中的应用。

背景信息

The PDIK1L (P21 (RAC1) Activated Kinase 1-Like) antibody is a tool used to study the PDIK1L protein, a serine/threonine kinase implicated in cellular signaling pathways. PDIK1L, also known as PLEKHK1. contains a pleckstrin homology (PH) domain and a kinase domain, suggesting roles in protein-protein interactions and phosphorylation-dependent regulation. It shares homology with PDIK1A, another kinase involved in cell cycle control and apoptosis. Research indicates PDIK1L interacts with 14-3-3 proteins, which modulate its activity and localization, linking it to processes like cell proliferation, survival, and stress responses. The antibody is commonly used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to detect endogenous PDIK1L levels, assess post-translational modifications, or explore its tissue-specific expression. Studies have highlighted its potential relevance in cancer, neurodegenerative diseases, and metabolic disorders, though its precise biological functions remain under investigation. Validated for specificity in human, mouse, and rat samples, this antibody aids in elucidating PDIK1L's role in signaling networks and its therapeutic potential as a biomarker or drug target.

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