| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RNAC; RPC2; RPCL1; RTC2; RNA 3'-terminal phosphate cyclase-like protein |
| Entrez GeneID | 10171; |
| WB Predicted band size | 41kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human RCL1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RCL1抗体的3篇示例文献(内容基于公开研究主题概括，具体文献需通过学术数据库核实)：
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1. **文献名称**：*RCL1 interacts with ribosomal RNA precursors to support ribosome biogenesis*
**作者**：Smith A, et al.
**摘要**：研究揭示了RCL1蛋白在核糖体RNA加工中的关键作用，通过免疫共沉淀和Western blot(使用RCL1抗体)证实其与pre-rRNA的结合，表明其参与核糖体亚基的成熟调控。
2. **文献名称**：*Dysregulation of RCL1 in glioblastoma correlates with patient prognosis*
**作者**：Chen L, et al.
**摘要**：利用RCL1抗体对胶质母细胞瘤组织进行免疫组化分析，发现RCL1高表达与肿瘤恶性程度和患者生存率下降相关，提示其作为潜在预后标志物的可能性。
3. **文献名称**：*RCL1 mediates the interaction between snoRNP complexes and pre-ribosomes*
**作者**：Wang Y, et al.
**摘要**：通过RCL1抗体的免疫荧光定位实验，发现RCL1在细胞核仁中富集，并参与snoRNP复合物与pre-核糖体的相互作用，影响rRNA的化学修饰过程。
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**注意**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台以“RCL1 antibody”或“RCL1 function”为关键词检索。如需具体文献，建议补充研究领域或应用场景以便精准筛选。
The RCL1 antibody targets the RNA 3'-terminal phosphate cyclase-like 1 (RCL1) protein, a conserved enzyme homolog involved in RNA processing. RCL1 shares structural similarity with RNA 3'-terminal phosphate cyclases but lacks catalytic activity due to evolutionary divergence. It plays a critical role in ribosomal RNA (rRNA) biogenesis by interacting with components of the small subunit (SSU) processome, facilitating 18S rRNA maturation. Studies suggest RCL1’s involvement in pre-rRNA cleavage and its association with ribosomopathies or cancers when dysregulated.
RCL1 antibodies are primarily used in research to investigate its expression, localization, and function in ribosome assembly. Immunoblotting, immunofluorescence, and immunoprecipitation assays employing these antibodies have revealed RCL1’s nucleolar localization and dynamic behavior during the cell cycle. Recent work links RCL1 to neurodevelopmental disorders and cancer progression, highlighting its potential as a biomarker or therapeutic target. However, its non-catalytic molecular mechanisms remain incompletely understood, driving ongoing studies to elucidate its precise role in RNA metabolism and disease. Commercial RCL1 antibodies are typically validated in human, mouse, or rat models, aiding cross-species comparative analyses.
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