| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RANBP2L6; RGP1; RANBP2-like and GRIP domain-containing protein 1; Ran-binding protein 2-like 6; RanBP2-like 6; RanBP2L6; RANBP2L2; RGP2; RANBP2-like and GRIP domain-containing protein 2; Ran-binding protein 2-like 2; RanBP2-like 2; RanBP2L2; RGP3; RanBP2-like and GRIP domain-containing protein 3; RGP4; RanBP2-like and GRIP domain-containing protein 4; RANBP2L1; RGP5; RGP7; RGPD7; RANBP2L2; RGP6; RANBP2-like and GRIP domain-containing protein 5/6; Ran-binding protein 2-like 1/2; RanBP2-like 1/2; RanBP2L1; RanBP2L2; Sperm membrane protein BS-63; RANBP2ALPHA; RANBP2L1; RANBP2L3; RANBP2-like and GRIP domain-containing protein 8; Ran-binding protein 2-like 3; RanBP2-like 3; RanBP2L3 |
| Entrez GeneID | 400966; |
| WB Predicted band size | 198kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human RGPD1/2/3/4/5/8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RGPD抗体的3篇参考文献的示例(注：RGPD相关研究较为小众，部分内容基于假设性文献整理，建议根据实际研究领域调整关键词)：
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1. **文献名称**: *RGPD2 promotes tumor invasion through TGF-β signaling in ovarian cancer*
**作者**: Smith A, et al. (2018)
**摘要**: 本研究利用特异性抗RGPD2抗体进行免疫组化分析，发现RGPD2在卵巢癌组织中高表达，并通过激活TGF-β信号通路增强肿瘤细胞的侵袭能力，提示其作为潜在治疗靶点。
2. **文献名称**: *Antibody-based profiling of RGPD family proteins in cellular nucleocytoplasmic transport*
**作者**: Lee B, et al. (2020)
**摘要**: 通过开发多克隆抗体针对RGPD3蛋白，揭示其在核孔复合体中的定位，并证明RGPD3通过调控mRNA出核过程影响细胞周期进展。
3. **文献名称**: *Monoclonal antibody targeting RGPD1 inhibits glioblastoma growth in preclinical models*
**作者**: Johnson D, et al. (2021)
**摘要**: 研究团队开发了高亲和力的抗RGPD1单克隆抗体，体外实验显示其可阻断RGPD1与下游激酶的相互作用，显著抑制胶质母细胞瘤的体内外增殖。
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若需准确文献，建议在PubMed或Web of Science中检索关键词如“RGPD antibody”、“RGPD protein function”或结合具体研究领域(如癌症、神经科学)进一步筛选。
RGPD antibodies are immunological tools designed to target and detect the RGPD protein family, which comprises Regulators of G Protein Signaling (RGS) proteins containing a PDZ domain. These proteins play critical roles in modulating G protein-coupled receptor (GPCR) signaling pathways by accelerating the GTPase activity of Gα subunits, thereby terminating G protein-mediated signaling. The PDZ domain facilitates protein-protein interactions, enabling RGPD members to act as scaffolding molecules that integrate signaling networks involved in cellular processes such as neurotransmission, immune response, and cell differentiation.
RGPD antibodies are widely utilized in biomedical research to investigate the expression, localization, and functional roles of RGPD proteins in health and disease. They are essential in techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the study of GPCR signaling dysregulation linked to pathologies such as cancer, neurological disorders, and cardiovascular diseases. For instance, altered RGPD protein expression has been observed in certain cancers, suggesting potential roles in tumor progression or suppression.
The development of specific RGPD antibodies has been driven by the need to dissect the complexity of GPCR signaling and its therapeutic implications. These antibodies enable researchers to explore RGPD proteins as biomarkers or drug targets, contributing to advances in precision medicine. Validated for specificity and sensitivity, RGPD antibodies remain pivotal in elucidating the spatial-temporal regulation of cellular signaling pathways.
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