| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Vacuolar protein sorting-associated protein 26B; Vesicle protein sorting 26B |
| Entrez GeneID | 112936; |
| WB Predicted band size | 39kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human VPS26B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于VPS26B抗体的3篇参考文献及其摘要概括(文献标题和作者为虚构示例，仅供参考格式)：
1. **文献名称**：*Structural characterization of VPS26B and its role in retromer complex assembly*
**作者**：Li, X., et al.
**摘要**：该研究解析了VPS26B蛋白的三维结构，发现其通过与VPS35亚基的相互作用参与逆转运复合体(retromer)的组装，并开发了特异性抗体用于检测其在细胞内的定位。
2. **文献名称**：*VPS26B antibody validation in neurodegenerative disease models*
**作者**：Smith, J., et al.
**摘要**：通过Western blot和免疫组化验证了VPS26B抗体的特异性，发现其在阿尔茨海默病模型中表达异常，提示VPS26B可能参与神经退行性疾病的病理过程。
3. **文献名称**：*Functional interplay between VPS26A and VPS26B in endosomal trafficking*
**作者**：Chen, Y., et al.
**摘要**：利用基因敲除和抗体标记技术，揭示了VPS26B与VPS26A在内涵体膜蛋白分选中的互补功能，抗体实验证实两者在不同细胞类型中的表达差异。
(注：以上文献为示例性内容，实际文献需通过PubMed或Google Scholar检索关键词“VPS26B antibody”获取。)
VPS26B antibody is a research tool designed to detect and study VPS26B, a protein belonging to the vacuolar protein sorting-associated (VPS) family. VPS26B is a component of the endosomal sorting complex required for transport (ESCRT) pathway, which regulates intracellular trafficking, lysosomal degradation, and membrane dynamics. Unlike its homolog VPS26A, which is part of the retromer complex involved in endosome-to-Golgi retrieval, VPS26B has distinct roles, potentially linked to alternative trafficking pathways or specialized cellular processes. Its precise biological functions remain under investigation, but studies suggest associations with cancer progression, neurological disorders, and receptor signaling modulation.
Antibodies targeting VPS26B enable researchers to explore its expression patterns, subcellular localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. These antibodies are often validated for specificity using knockout cell lines or siRNA-mediated knockdown to confirm minimal cross-reactivity with VPS26A or other paralogs. Commercial VPS26B antibodies are typically available as polyclonal or monoclonal formulations, with applications spanning basic cell biology, disease mechanism studies, and biomarker research. In cancer contexts, for example, VPS26B expression has been correlated with tumor metastasis, making its antibody a valuable tool for profiling clinical samples. Researchers also employ these antibodies to dissect ESCRT pathway complexities, particularly in contexts where VPS26B’s role diverges from canonical retromer functions. Proper validation and optimization remain critical due to potential batch variability and tissue-specific expression challenges.
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