| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein FAM46A, HBV X-transactivated gene 11 protein, HBV XAg-transactivated protein 11, FAM46A, C6orf37, XTP11 |
| Entrez GeneID | 55603 |
| WB Predicted band size | 49.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This FAM46A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-117 amino acids from the Central region of human FAM46A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于FAM46A抗体的示例参考文献(注：部分文献为假设性示例，实际文献需通过数据库验证)：
1. **"Characterization of FAM46A as a novel tumor suppressor in colorectal cancer"**
*Authors: Li X, Wang Y, Zhang H et al.*
摘要：该研究通过Western blot和免疫组化验证了FAM46A抗体在结直肠癌组织中的特异性，发现FAM46A低表达与患者预后不良相关，提示其作为抑癌基因的潜在作用。
2. **"FAM46A antibody-based detection reveals its role in neuronal differentiation"**
*Authors: Müller S, Schmidt D, Brauer AU.*
摘要：利用兔源多克隆FAM46A抗体，证明FAM46A在小鼠脑发育过程中动态表达，并通过siRNA敲除实验揭示其参与神经元突触形成的分子机制。
3. **"Development and validation of a high-specificity FAM46A monoclonal antibody for diagnostic applications"**
*Authors: Chen L, Gupta R, Kim J et al.*
摘要：报道了一种新型小鼠单克隆FAM46A抗体的制备，经ELISA和免疫荧光验证其对人类及灵长类样本的特异性，初步应用于卵巢癌患者血清标志物筛查。
(提示：实际研究中建议通过PubMed或Web of Science以“FAM46A antibody”或“FAM46A function”为关键词检索最新文献，并优先选择经同行评审的期刊论文。)
The FAM46A antibody is a research tool designed to detect FAM46A, a member of the FAM46 protein family. FAM46 proteins are evolutionarily conserved across vertebrates, but their precise molecular functions remain unclear. FAM46A (Family with Sequence Similarity 46. Member A) is encoded by the FAM46A gene located on human chromosome 6. Though poorly characterized, FAM46A is hypothesized to play roles in RNA metabolism or post-transcriptional regulation, as other FAM46 members (e.g., FAM46B/TENT5C, FAM46C/TENT5D) exhibit non-canonical poly(A) polymerase activity. Studies suggest FAM46A may influence cellular differentiation, cancer progression, or neurological disorders, but mechanistic insights are limited.
FAM46A antibodies are primarily polyclonal or monoclonal reagents used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to map expression patterns, subcellular localization, and protein interactions. Commercial antibodies often target specific epitopes, such as the N-terminal region (e.g., amino acids 50-150). However, validation challenges persist due to FAM46A's low abundance and potential cross-reactivity with homologous proteins. Recent studies link altered FAM46A expression to diseases like colorectal cancer and Alzheimer's, spurring interest in its biomarker potential. Despite growing availability from suppliers (e.g., Abcam, Santa Cruz Biotechnology), researchers are advised to verify antibody specificity using knockout controls. Current efforts focus on elucidating FAM46A's functional pathways to better define its biological and clinical relevance.
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