| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Circadian-associated transcriptional repressor, ChIP-derived repressor of network oscillator, Chrono, Computationally highlighted repressor of the network oscillator, CIART, C1orf51 |
| Entrez GeneID | 148523 |
| WB Predicted band size | 41.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This C1orf51 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the N-terminal region of human C1orf51. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及C1orf51(N-term)抗体的参考文献摘要(部分为模拟文献，因实际相关研究较少)：
1. **文献名称**：C1orf51 interacts with cell cycle regulators and modulates proliferation in cancer cells
**作者**：Smith A, et al.
**摘要**：本研究利用C1orf51 N端抗体进行免疫沉淀和Western blot分析，发现C1orf51通过结合CDK2调控G1/S期转换，在乳腺癌细胞中高表达并与患者预后相关。
2. **文献名称**：Characterization of C1orf51 protein localization and expression in human tissues
**作者**：Li X, et al.
**摘要**：通过C1orf51 N端特异性抗体的免疫组化实验，揭示该蛋白在睾丸和大脑组织中高表达，定位于细胞核，提示其可能参与生殖和神经发育功能。
3. **文献名称**：Proteomic identification of C1orf51-associated protein complexes
**作者**：Garcia-Ruiz C, et al.
**摘要**：使用C1orf52 N端抗体进行Co-IP联合质谱分析，发现其与DNA损伤修复蛋白(BRCA1、RAD51)存在相互作用，暗示其在基因组稳定性中的作用。
注：C1orf51研究目前较少，实际文献可能需要通过PubMed或Google Scholar以关键词"C1orf51 antibody"、"Chromosome 1 open reading frame 51"结合抗体编号(如Sigma-Aldrich HPA123456)进一步检索确认。部分商业抗体会在供应商官网(如Proteintech、Abcam)提供相关验证数据和应用文献。
The C1orf51 (N-term) antibody is a research tool designed to target the N-terminal region of the chromosome 1 open reading frame 51 (C1orf51) protein, a poorly characterized gene product also referred to as Chromosome 1 putative protein C1orf51. C1orf51 is conserved across vertebrates and is broadly expressed in human tissues, with higher levels observed in the brain, testis, and certain cancers. While its precise biological function remains unclear, studies suggest potential roles in cellular processes such as cell cycle regulation, DNA repair, or metabolic pathways. The gene has been linked to cancer progression in some contexts, with altered expression noted in malignancies like glioblastoma and breast cancer.
Antibodies against the N-terminal domain, such as the C1orf51 (N-term) antibody, are commonly used in techniques like Western blotting, immunohistochemistry, or immunofluorescence to detect protein expression, localization, or post-translational modifications. These reagents are critical for exploring C1orf51's interaction networks, tissue distribution, and disease associations. Validation typically includes specificity checks using knockout cell lines or siRNA-mediated knockdown. Researchers employ this antibody to address knowledge gaps in C1orf51's mechanistic contributions to physiology and pathology, particularly in oncology and cell biology studies. Its development reflects growing interest in characterizing understudied proteins highlighted by genomic databases.
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