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Rabbit Polyclonal ZDHHC1(N-term) Antibody

  • 中文名： ZDHHC1 (N-term)抗体
  • 别    名： Probable palmitoyltransferase ZDHHC1, DHHC domain-containing cysteine-rich protein 1, Zinc finger DHHC domain-containing protein 1, DHHC-1, Zinc finger protein 377, ZDHHC1, C16orf1, ZNF377
货号: IPDX30757
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProbable palmitoyltransferase ZDHHC1, DHHC domain-containing cysteine-rich protein 1, Zinc finger DHHC domain-containing protein 1, DHHC-1, Zinc finger protein 377, ZDHHC1, C16orf1, ZNF377
Entrez GeneID29800
WB Predicted band size54.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis ZDHHC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human ZDHHC1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ZDHHC1 (N-term)抗体的3篇参考文献示例(基于领域内常见研究方向，内容为模拟概括)：

1. **文献名称**：*"ZDHHC1-mediated palmitoylation regulates subcellular localization and stability of the membrane protein ABCA1"*

**作者**：Smith J, et al.

**摘要**：本研究利用ZDHHC1 (N-term)抗体通过Western blot和免疫荧光技术，揭示了ZDHHC1在HEK293细胞中对ABCA1蛋白的棕榈酰化修饰作用及其对ABCA1膜定位的影响。

2. **文献名称**：*"Expression profiling of DHHC family proteins in human cancers identifies ZDHHC1 as a potential biomarker in hepatocellular carcinoma"*

**作者**：Li X, et al.

**摘要**：作者使用ZDHHC1 (N-term)特异性抗体进行免疫组织化学分析，发现ZDHHC1在肝癌组织中显著高表达，且与患者预后不良相关，提示其作为肿瘤标志物的潜力。

3. **文献名称**：*"Neuronal palmitoyltransferase ZDHHC1 modulates synaptic plasticity through glutamate receptor trafficking"*

**作者**：Wang Y, et al.

**摘要**：通过ZDHHC1 (N-term)抗体的免疫沉淀实验，该研究证实ZDHHC1与AMPA受体亚基结合并调控其突触后膜定位，从而影响小鼠海马神经元的突触可塑性。

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**注**：以上文献为示例性概括，实际文献需通过PubMed、Google Scholar等数据库检索确认。若需具体文章，建议以“ZDHHC1 antibody”、“N-terminal epitope”及“palmitoylation”为关键词进一步筛选。

背景信息

The ZDHHC1 (N-term) antibody is a specific immunological tool designed to target the N-terminal region of the ZDHHC1 protein, a member of the DHHC (Asp-His-His-Cys) family of palmitoyltransferases. These enzymes catalyze protein palmitoylation, a post-translational modification critical for membrane anchoring, protein trafficking, and signal transduction. ZDHHC1 is implicated in diverse cellular processes, including synaptic plasticity, cancer progression, and immune regulation. The antibody is typically generated in hosts like rabbits or mice using immunogenic peptides derived from the N-terminal sequence of human ZDHHC1. It is widely employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study ZDHHC1 expression, localization, and interactions in tissues or cultured cells. Researchers utilize this antibody to explore ZDHHC1's role in diseases like cancer (where its dysregulation affects metastasis) or neurological disorders (linked to aberrant palmitoylation). Validation often includes knockout controls to confirm specificity. As palmitoylation gains attention in therapeutic targeting, this antibody serves as a key reagent for mechanistic studies and potential biomarker discovery. Commercial versions may vary in clonality (monoclonal/polyclonal) and conjugate formats (e.g., HRP, FITC).

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