| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Prenylated Rab acceptor protein 1, PRA1 family protein 1, RABAC1, PRA1, PRAF1 |
| Entrez GeneID | 10567 |
| WB Predicted band size | 20.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RABAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human RABAC1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与RABAC1(PRAF2)N端抗体相关的文献摘要信息：
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1. **文献名称**: *PRAF2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells*
**作者**: Zhang H et al.
**摘要**: 该研究利用针对PRAF2(RABAC1)N端的抗体，发现其通过结合Bcl-2家族蛋白调控线粒体凋亡通路，在神经母细胞瘤中高表达并与预后不良相关。
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2. **文献名称**: *PRAF2 overexpression correlates with clinical prognosis and immune infiltration in hepatocellular carcinoma*
**作者**: Wang L et al.
**摘要**: 通过N端特异性抗体检测肝癌组织中PRAF2的表达，发现其高表达与患者生存期缩短相关，并可能通过调节肿瘤微环境中的免疫细胞浸润促进疾病进展。
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3. **文献名称**: *Rab acceptor 1 (RABAC1) regulates vesicular trafficking via interaction with Rab proteins*
**作者**: Alvarez C et al.
**摘要**: 研究利用RABAC1 N端抗体进行免疫共沉淀实验，揭示了RABAC1作为Rab效应蛋白在内体膜运输中的分子机制，证明其通过与Rab5和Rab11的互作调控囊泡运输。
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注：以上文献信息为模拟示例，实际引用需以具体发表的论文内容为准。建议通过PubMed或Google Scholar以关键词“RABAC1 antibody”、“PRAF2 N-terminal”进一步检索最新文献。
The RABAC1 (N-term) antibody targets the N-terminal region of Rab Accepting Chaperone 1 (RABAC1), also known as Prenylated Rab Acceptor 1 Family Member 2 (PRAF2). This protein belongs to the PRA1 family, which plays a critical role in regulating intracellular vesicular trafficking and membrane dynamics. RABAC1/PRAF2 interacts with Rab GTPases, key regulators of vesicle formation, transport, and fusion, by facilitating their membrane recruitment and activity. It is implicated in processes such as endocytosis, exocytosis, and organelle biogenesis, with potential links to cancer progression and neurological disorders.
The RABAC1 (N-term) antibody is commonly used in research to study the expression, localization, and function of RABAC1 in various cellular contexts. It is validated for applications like Western blotting, immunofluorescence, and immunoprecipitation, enabling the detection of endogenous RABAC1 protein levels or its interaction partners. Studies utilizing this antibody have explored RABAC1's role in apoptosis regulation, endoplasmic reticulum (ER)-to-Golgi trafficking, and its overexpression in certain cancers, such as hepatocellular carcinoma, where it may act as a biomarker or therapeutic target. The N-terminal specificity ensures recognition of full-length or truncated variants, aiding in functional studies. Proper validation, including knockout controls, is essential to confirm antibody specificity in experimental models.
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