| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Heat shock protein 105 kDa, Antigen NY-CO-25, Heat shock 110 kDa protein, HSPH1, HSP105, HSP110, KIAA0201 |
| Entrez GeneID | 10808 |
| WB Predicted band size | 96.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HSPH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-579 amino acids from the Central region of human HSPH1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下为假设的3篇关于HSPH1抗体的参考文献示例(非真实文献，仅供格式参考)：
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1. **文献名称**：*HSPH1 Expression in Glioblastoma: A Prognostic Biomarker Study*
**作者**：Smith A, et al.
**摘要**：本研究通过免疫组化(使用HSPH1特异性抗体)发现HSPH1在胶质母细胞瘤组织中高表达，且与患者生存期缩短显著相关，提示其可作为潜在预后标志物。
2. **文献名称**：*Targeting HSPH1 in Triple-Negative Breast Cancer via Antibody-Based Inhibition*
**作者**：Chen L, et al.
**摘要**：利用HSPH1抗体阻断其功能后，三阴性乳腺癌细胞增殖和转移能力显著下降，表明HSPH1是治疗此类癌症的潜在靶点。
3. **文献名称**：*HSPH1 Antibody Validation for Stress Response Studies in Neuronal Models*
**作者**：Park J, et al.
**摘要**：研究通过Western blot和免疫荧光(采用HSPH1抗体)验证了热休克条件下神经元中HSPH1的核转位现象，揭示了其在神经保护中的动态调控机制。
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注：以上文献为模拟内容，实际研究中建议通过PubMed、Web of Science等平台以“HSPH1 antibody”为关键词检索真实文献。
HSPH1 (Heat Shock Protein Family H1), also known as HSP105. is a member of the heat shock protein (HSP) family, which plays critical roles in cellular stress responses. As a molecular chaperone, HSPH1 assists in protein folding, prevents aggregation of misfolded proteins, and supports cellular recovery under stress conditions such as heat shock, oxidative stress, or toxin exposure. It belongs to the HSP110 subfamily, characterized by its high molecular weight (∼105 kDa) and structural similarity to HSP70. though it exhibits distinct functional properties.
HSPH1 antibodies are essential tools for studying the expression, localization, and function of HSPH1 in various biological contexts. These antibodies enable researchers to detect HSPH1 in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Studies using HSPH1 antibodies have revealed its dual role: under mild stress, it promotes cell survival by stabilizing client proteins, while severe stress triggers its involvement in apoptotic pathways. Dysregulation of HSPH1 has been implicated in cancer progression, neurodegenerative diseases, and thermotolerance mechanisms, making it a potential therapeutic target.
Commercially available HSPH1 antibodies are typically validated for specificity through knockdown/knockout controls. Researchers utilize these antibodies to explore HSPH1's interactions with other chaperones, its role in proteostasis, and its diagnostic or prognostic value in diseases like glioblastoma or colorectal cancer.
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