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Rabbit Polyclonal CYP2C19(N-term) Antibody

  • 中文名： CYP2C19 (N-term)抗体
  • 别    名： Cytochrome P450 2C19, 11413-, (R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, CYPIIC17, CYPIIC19, Cytochrome P450-11A, Cytochrome P450-254C, Mephenytoin 4-hydroxylase, CYP2C19
货号: IPDX30444
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCytochrome P450 2C19, 11413-, (R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, CYPIIC17, CYPIIC19, Cytochrome P450-11A, Cytochrome P450-254C, Mephenytoin 4-hydroxylase, CYP2C19
Entrez GeneID1557
WB Predicted band size55.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CYP2C19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-108 amino acids from the N-terminal region of human CYP2C19.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于CYP2C19(N-term)抗体的参考文献示例(部分为假设性描述，供参考)：

1. **"Characterization of a Monoclonal Antibody Specific to Human CYP2C19 N-Terminal Domain"**

*作者：Smith A, et al.*

摘要：研究开发了一种针对CYP2C19氨基末端(N-term)的小鼠单克隆抗体，验证了其在Western blot和免疫组织化学中的特异性，证明其可有效区分CYP2C19与其他CYP2C亚家族成员(如CYP2C9)，适用于肝组织样本中蛋白表达的定量分析。

2. **"CYP2C19 Genetic Polymorphisms and Protein Expression in Human Liver"**

*作者：Zhou Q, et al.*

摘要：利用抗CYP2C19(N-term)抗体检测不同基因型个体的肝脏样本，发现CYP2C19*2和*3变异体的蛋白表达显著降低，提示该抗体在关联基因型与表型研究中的实用性。

3. **"Development of a Polyclonal Antibody for CYP2C19 Localization in Gastrointestinal Tissues"**

*作者：Lee B, et al.*

摘要：研究报道了一种兔源多克隆抗体的制备，特异性靶向CYP2C19的N端区域，成功用于免疫荧光染色，揭示了CYP2C19在胃黏膜细胞中的表达，为研究其在质子泵抑制剂代谢中的作用提供工具。

4. **"Impact of CYP2C19 Variants on Clopidogrel Response: Antibody-Based Quantification in Clinical cohorts"**

*作者：Johnson R, et al.*

摘要：通过抗CYP2C19(N-term)抗体定量患者肝活检样本中的酶水平，结合药代动力学分析，证实CYP2C19低表达与氯吡格雷治疗低反应性显著相关。

**备注**：以上文献名称与摘要均为示例性质，实际文献需通过PubMed或Google Scholar以关键词“CYP2C19 antibody N-terminal”检索获取最新研究。真实文献可能包括抗体验证、临床相关性或方法学开发等内容。

背景信息

The CYP2C19 (N-term) antibody is designed to detect the N-terminal region of the cytochrome P450 2C19 enzyme, a key hepatic protein involved in metabolizing numerous drugs, including clopidogrel, proton pump inhibitors (e.g., omeprazole), and antidepressants. CYP2C19 exhibits genetic polymorphism, with variants (e.g., *2. *3. *17) significantly influencing enzyme activity, leading to categorization into phenotypes such as poor, intermediate, extensive, or ultrarapid metabolizers. These variations impact drug efficacy and toxicity, driving pharmacogenomic research for personalized therapy. The N-terminal-specific antibody is critical for distinguishing full-length CYP2C19 from splice variants or degradation products in experimental assays like Western blotting, immunohistochemistry, or ELISA. It aids in studying tissue-specific expression, drug-induced enzyme regulation, and interindividual metabolic variability. Research using this antibody contributes to understanding drug-drug interactions, optimizing dosing regimens, and predicting adverse reactions. Its application extends to clinical studies exploring associations between CYP2C19 expression patterns and therapeutic outcomes, particularly in cardiology (antiplatelet therapy) and gastroenterology (acid-related disorders). Reliable detection of CYP2C19 supports translational efforts to bridge genetic data with functional protein expression in diverse populations.

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