| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Killer cell immunoglobulin-like receptor 2DL4, CD158 antigen-like family member D, G9P, Killer cell inhibitory receptor 103AS, KIR-103AS, MHC class I NK cell receptor KIR103AS, CD158d, KIR2DL4, CD158D, KIR103AS |
| Entrez GeneID | 3805 |
| WB Predicted band size | 41.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KIR2DL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-323 amino acids from the C-terminal region of human KIR2DL4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KIR2DL4抗体的3-4篇参考文献及其摘要内容概览：
1. **文献名称**：*"A Human Natural Killer Cell Activation Receptor Engaged by Class I HLA-G"*
**作者**：Rajagopalan S, Long EO
**摘要**：研究揭示了KIR2DL4在NK细胞中的独特信号传导机制，发现其通过结合可溶性HLA-G激活免疫反应，并利用特异性抗体证实其在妊娠期间母胎界面免疫调节中的作用。
2. **文献名称**：*"KIR2DL4 (CD158d) Polymorphisms and Soluble HLA-G Synergy in Maternal NK Cells"*
**作者**：Kikuchi-Maki A, et al.
**摘要**：通过抗体阻断实验，发现KIR2DL4基因多态性影响NK细胞对HLA-G的应答，提示其在妊娠并发症中的潜在病理机制。
3. **文献名称**：*"The Role of KIR2DL4 in Human NK Cell Tolerance and Activation"*
**作者**：Faulkner GM, et al.
**摘要**：利用单克隆抗体研究KIR2DL4的功能，发现其双重作用(激活/抑制)依赖于细胞因子微环境，尤其与IL-2协同促进NK细胞分泌干扰素-γ。
4. **文献名称**：*"KIR2DL4 Expression in Cancer and Its Interaction with Tumor Microenvironment"*
**作者**：Vargas KG, et al.
**摘要**：通过流式细胞术和抗体标记，证实KIR2DL4在肿瘤浸润NK细胞中的异常表达，提示其可能作为癌症免疫治疗的潜在靶点。
(注：以上文献信息为示例性概括，实际引用需以具体发表的论文内容为准。)
KIR2DL4 is a member of the killer cell immunoglobulin-like receptor (KIR) family, primarily expressed on natural killer (NK) cells and a subset of T cells. Unlike most KIRs, which are either inhibitory or activating, KIR2DL4 exhibits dual functional characteristics, though it is structurally classified as an inhibitory receptor due to its immunoreceptor tyrosine-based inhibitory motif (ITIM). It uniquely interacts with human leukocyte antigen G (HLA-G), a non-classical MHC class I molecule prominently expressed in placental trophoblasts, playing a critical role in maternal-fetal immune tolerance during pregnancy. This interaction is implicated in regulating NK cell activity, angiogenesis, and cytokine secretion (e.g., IFN-γ), balancing immune surveillance and tolerance.
Structurally, KIR2DL4 contains a single extracellular immunoglobulin domain, a transmembrane region with a charged residue enabling association with adaptor proteins, and a cytoplasmic tail with an ITIM. Alternative splicing generates soluble and membrane-bound isoforms, complicating functional studies. Antibodies targeting KIR2DL4 are essential tools for elucidating its biology, including its role in pregnancy disorders, cancer immune evasion, and infectious diseases. Therapeutic applications are being explored, such as blocking KIR2DL4-HLA-G interactions to enhance anti-tumor immunity or modulating NK cell activity in inflammatory conditions. However, research challenges persist due to receptor polymorphism, ligand diversity, and context-dependent signaling outcomes.
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