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Recombinant  Human TRIM67 Protein

  • 中文名: 重组人(TRIM67)蛋白
  • 别    名: TNL; TRI67_HUMAN; Trim67; TRIM9 like Protein; TRIM9-like Protein; Tripartite motif containing 67; Tripartite motif-containing Protein 67
货号: PAX2000-12178
Price: ¥询价
数量:
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点TRIM67
Uniprot NoQ6ZTA4
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-783 aa
活性数据MEEELKCPVC GSLFREPIIL PCSHNVCLPC ARTIAVQTPD GEQHLPQPLL LSRGSGLQAG AAAAASLEHD AAAGPACGGA GGSAAGGLGG GAGGGGDHAD KLSLYSETDS GYGSYTPSLK SPNGVRVLPM VPAPPGSSAA AARGAACSSL SSSSSSITCP QCHRSASLDH RGLRGFQRNR LLEAIVQRYQ QGRGAVPGTS AAAAVAICQL CDRTPPEPAA TLCEQCDVLY CSACQLKCHP SRGPFAKHRL VQPPPPPPPP AEAASGPTGT AQGAPSGGGG CKSPGGAGAG ATGGSTARKF PTCPEHEMEN YSMYCVSCRT PVCYLCLEEG RHAKHEVKPL GAMWKQHKAQ LSQALNGVSD KAKEAKEFLV QLKNILQQIQ ENGLDYEACL VAQCDALVDA LTRQKAKLLT KVTKEREHKL KMVWDQINHC TLKLRQSTGL MEYCLEVIKE NDPSGFLQIS DALIKRVQVS QEQWVKGALE PKVSAEFDLT LDSEPLLQAI HQLDFIQMKC RVPPVPLLQL EKCCTRNNSV TLAWRMPPFT HSPVDGYILE LDDGAGGQFR EVYVGKETLC TIDGLHFNST YNARVKAFNS SGVGPYSKTV VLQTSDVAWF TFDPNSGHRD IILSNDNQTA TCSSYDDRVV LGTAAFSKGV HYWELHVDRY DNHPDPAFGV ARASVVKDMM LGKDDKAWAM YVDNNRSWFM HCNSHTNRTE GGVCKGATVG VLLDLNKHTL TFFINGQQQG PTAFSHVDGV FMPALSLNRN VQVTLHTGLE VPTNLGRPKL SGN
分子量83.8 kDa
蛋白标签His tag N-Terminus
缓冲液PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.


参考文献

以下是3篇关于TRIM67蛋白的参考文献及其摘要概括:

1. **"TRIM67 regulates exocytic vesicle trafficking and promotes axon extension"**

*Yamada S. et al., 2022*

该研究揭示了TRIM67通过调控囊泡运输机制,促进神经元轴突生长。实验表明TRIM67缺失会导致轴突发育缺陷,其作用可能与Rab11介导的膜运输通路相互作用相关。

2. **"The E3 ligase TRIM67 suppresses gastric cancer through destabilizing cIAP1"**

*Li X. et al., 2021*

发现TRIM67在胃癌中呈低表达,可通过泛素化修饰降解促癌蛋白cIAP1.抑制NF-κB信号通路。该研究确立了TRIM67作为新型肿瘤抑制因子的功能。

3. **"Structural basis for TRIM67’s role in innate immunity against viruses"**

*Zhang Y. et al., 2019*

解析了TRIM67的RING结构域介导抗病毒反应的分子机制,证明其通过K63-linked泛素化激活MAVS信号通路,从而增强宿主对RNA病毒(如VSV)的防御能力。

(注:以上文献信息为模拟示例,实际引用需核对具体论文内容。)


背景信息

TRIM67. a member of the tripartite motif (TRIM) protein family, is characterized by its conserved RING finger, B-box, and coiled-coil domains. TRIM proteins are ubiquitin E3 ligases involved in diverse cellular processes, including proliferation, differentiation, and innate immune responses. TRIM67. though less studied than other TRIMs like TRIM5 or TRIM21. has emerged as a key regulator in neuronal development, cellular membrane dynamics, and pathogen defense. It localizes to the cytoplasm and interacts with cytoskeletal components, influencing processes such as neurite outgrowth and synaptic connectivity. Studies in model organisms, like mice, highlight its role in brain development and synaptic plasticity. Additionally, TRIM67 exhibits antiviral activity by targeting viral particles for degradation and modulates antibacterial autophagy. Its involvement in cancer is context-dependent, acting as a tumor suppressor in some malignancies by promoting apoptosis, while potentially driving metastasis in others. Recent research also implicates TRIM67 in neurodegenerative disorders, though mechanisms remain unclear. Despite progress, its precise molecular pathways, substrate specificity, and regulatory networks require further exploration. TRIM67’s multifunctional nature underscores its therapeutic potential but complicates mechanistic understanding, necessitating advanced studies to disentangle its roles in health and disease.


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