| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TRIM62 |
| Uniprot No | Q9BVG3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-475 aa |
| 活性数据 | MACSLKDELL CSICLSIYQD PVSLGCEHYF CRRCITEHWV RQEAQGARDC PECRRTFAEP ALAPSLKLAN IVERYSSFPL DAILNARRAA RPCQAHDKVK LFCLTDRALL CFFCDEPALH EQHQVTGIDD AFDELQRELK DQLQALQDSE REHTEALQLL KRQLAETKSS TKSLRTTIGE AFERLHRLLR ERQKAMLEEL EADTARTLTD IEQKVQRYSQ QLRKVQEGAQ ILQERLAETD RHTFLAGVAS LSERLKGKIH ETNLTYEDFP TSKYTGPLQY TIWKSLFQDI HPVPAALTLD PGTAHQRLIL SDDCTIVAYG NLHPQPLQDS PKRFDVEVSV LGSEAFSSGV HYWEVVVAEK TQWVIGLAHE AASRKGSIQI QPSRGFYCIV MHDGNQYSAC TEPWTRLNVR DKLDKVGVFL DYDQGLLIFY NADDMSWLYT FREKFPGKLC SYFSPGQSHA NGKNVQPLRI NTVRI |
| 分子量 | 54.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于TRIM62蛋白的参考文献示例(文献信息为假设性示例，建议通过学术数据库核实)：
1. **文献名称**：*TRIM62 Acts as a Tumor Suppressor in Breast Cancer by Regulating Cell Proliferation*
**作者**：Kondo, T. et al.
**摘要**：该研究发现TRIM62在乳腺癌中低表达，其通过促进抑癌蛋白的泛素化降解抑制肿瘤细胞增殖，并调控NF-κB信号通路。
2. **文献名称**：*TRIM62 Mediates Ubiquitination of c-Myc to Modulate Hepatocellular Carcinoma Progression*
**作者**：Wang, L. et al.
**摘要**：研究揭示TRIM62通过泛素化修饰c-Myc蛋白，抑制肝癌细胞的迁移和侵袭，为潜在的治疗靶点提供了依据。
3. **文献名称**：*The Role of TRIM62 in Innate Immunity and Viral Infection Responses*
**作者**：Smith, J.A. & Chen, Z.
**摘要**：TRIM62通过介导RIG-I信号通路的泛素化，增强Ⅰ型干扰素产生，在抗病毒免疫应答中发挥关键作用。
4. **文献名称**：*TRIM62 Deficiency Promotes Colorectal Cancer Metastasis via Stabilizing β-Catenin*
**作者**：Zhang, Y. et al.
**摘要**：TRIM62缺失导致β-catenin蛋白稳定性增加，激活Wnt信号通路，进而促进结直肠癌转移。
**备注**：上述文献为模拟示例，请通过PubMed、Web of Science等平台搜索真实文献(关键词：TRIM62. cancer, ubiquitination, immune response)。
TRIM62 (Tripartite Motif-Containing Protein 62) is a member of the TRIM family, which is characterized by a conserved N-terminal tripartite motif (RING, B-box, and coiled-coil domains) and a variable C-terminal region. Functioning primarily as an E3 ubiquitin ligase, TRIM62 plays critical roles in regulating protein degradation, innate immunity, and cellular homeostasis. It is involved in diverse biological processes, including cell proliferation, apoptosis, and antiviral responses. Emerging studies highlight its dual roles in cancer: TRIM62 often acts as a tumor suppressor by promoting ubiquitination and degradation of oncoproteins (e.g., β-catenin in the Wnt/β-catenin pathway) or inhibiting pro-survival pathways (e.g., NF-κB signaling). Conversely, context-dependent oncogenic functions have also been reported, linked to tissue-specific interactions or dysregulation of its expression.
TRIM62 is broadly expressed in tissues, with aberrant expression observed in multiple cancers. Downregulation due to promoter hypermethylation or genetic mutations correlates with poor prognosis in hepatocellular carcinoma, breast cancer, and lung adenocarcinoma. Its tumor-suppressive activity involves destabilizing oncogenic substrates or modulating immune signaling. However, mechanistic details remain incompletely understood, particularly regarding its tissue-specific regulation and interaction networks. Further research is needed to clarify its pathophysiological roles and potential as a therapeutic target or biomarker in disease.
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