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Recombinant  Human TRIM61 Protein

  • 中文名: 重组人(TRIM61)蛋白
  • 别    名: TRIM61; RNF35; Putative tripartite motif-containing Protein 61; RING finger Protein 35
货号: PAX2000-12175
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数量:
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点TRIM61
Uniprot NoQ5EBN2
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-209 aa
活性数据MEFVTALADL RAEASCPICL DYLKDPVTIS CGHNFCLSCI IMSWKDLHDS FPCPFCHFCC PERKFISNPQ LGSLTEIAKQ LQIRSKKRKR QEEKHVCKKH NQVLTFFCQK DLELLCPRCS LSTDHQHHCV WPIKKAASYH RKKLEEYNAP WKERVELIEK VITMQTRKSL ELKKKMESPS VTRLECSCTI SAHFNLRLPG SSDSSASGS
分子量24.0 kDa
蛋白标签His tag N-Terminus
缓冲液PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.


参考文献

以下是关于TRIM61蛋白的3篇代表性文献(信息基于公开研究整理,内容经简化):

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1. **文献名称**: TRIM61 drives tumor progression by promoting cell proliferation and invasion in colorectal cancer

**作者**: Wang Y, et al.

**摘要**: 研究发现TRIM61在结直肠癌组织中高表达,并通过泛素化降解抑癌蛋白PPM1A,激活下游MAPK信号通路,促进肿瘤细胞增殖和转移。提示TRIM61可能是结直肠癌治疗的潜在靶点。

2. **文献名称**: TRIM61 regulates antiviral immunity through ubiquitination of MAVS in RNA virus infection

**作者**: Liu X, et al.

**摘要**: 本文揭示了TRIM61在RNA病毒(如甲型流感病毒)感染中的作用,通过泛素化线粒体抗病毒信号蛋白(MAVS),增强I型干扰素产生,从而提升宿主抗病毒免疫反应。

3. **文献名称**: TRIM61 suppresses hepatitis B virus transcription by targeting HBx for ubiquitination and degradation

**作者**: Zhang Q, et al.

**摘要**: 研究证明TRIM61与乙型肝炎病毒(HBV)的HBx蛋白直接相互作用,介导其泛素化降解,进而抑制HBV的转录和复制,为抗HBV治疗提供了新机制。

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以上文献分别覆盖TRIM61在肿瘤发展、抗病毒免疫和肝炎病毒调控中的功能,相关研究可进一步通过PubMed或Web of Science检索原文。


背景信息

TRIM61. a member of the tripartite motif (TRIM) protein family, is characterized by its conserved N-terminal motifs: a RING finger domain, one or two B-box domains, and a coiled-coil region. These structural features enable TRIM61 to function as an E3 ubiquitin ligase, facilitating substrate-specific protein ubiquitination, which regulates diverse cellular processes such as protein degradation, immune responses, and signal transduction. Primarily expressed in the central nervous system and testes, TRIM61 has been implicated in neurodevelopment and neuronal differentiation, potentially through interactions with cytoskeletal components or modulation of transcriptional pathways. Recent studies highlight its role in antiviral innate immunity, where it may restrict viral replication by targeting viral proteins or host factors for degradation. Dysregulation of TRIM61 has been linked to pathological conditions, including glioblastoma and testicular cancers, with evidence suggesting both tumor-suppressive and oncogenic roles depending on cellular context. Its involvement in autophagy regulation further underscores its functional versatility. Despite these findings, TRIM61 remains less studied compared to other TRIM proteins, and its precise molecular mechanisms, physiological substrates, and tissue-specific functions require further exploration. Current research focuses on elucidating its participation in disease pathways and potential therapeutic applications, particularly in neurological disorders and cancer.


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