| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/300 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PGR18; Probable G-protein coupled receptor 115; G-protein coupled receptor PGR18 |
| Entrez GeneID | 221393; |
| WB Predicted band size | 110kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GPR115. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GPR115抗体的模拟参考文献(仅供参考，实际文献需通过学术数据库检索)：
1. **文献名称**：*"Development of a monoclonal antibody targeting GPR115 for functional studies in cancer progression"*
**作者**：Smith A, et al.
**摘要**：该研究报道了一种新型抗GPR115单克隆抗体的开发，验证了其在免疫印迹和免疫组化中的特异性，并发现GPR115在乳腺癌细胞中高表达，提示其可能参与肿瘤侵袭调控。
2. **文献名称**：*"GPR115 antibody-based detection reveals its role in neuronal differentiation and Alzheimer's disease pathology"*
**作者**：Zhang L, et al.
**摘要**：通过GPR115抗体标记，发现该受体在小鼠脑组织中特定神经元亚群表达，且在阿尔茨海默病模型中出现表达下调，提示其可能与神经退行性变相关。
3. **文献名称**：*"A novel anti-GPR115 antibody inhibits ligand-induced signaling and ameliorates metabolic dysfunction in obese mice"*
**作者**：Johnson R, et al.
**摘要**：研究设计了一种阻断型GPR115抗体，证明其可抑制受体激活并改善高脂饮食小鼠的胰岛素抵抗，为代谢性疾病治疗提供了潜在工具。
4. **文献名称**：*"GPR115 antibody screening identifies its interaction with extracellular matrix proteins in tissue remodeling"*
**作者**：Lee S, et al.
**摘要**：利用GPR115抗体进行共沉淀实验，揭示了该受体与纤维连接蛋白的相互作用，表明其在组织修复和纤维化疾病中的潜在作用机制。
**注**：以上内容为模拟生成，实际文献需通过PubMed、Google Scholar等平台检索关键词(如“GPR115 antibody”、“GPR115 function”)获取。
GPR115 (G protein-coupled receptor 115), also known as ADGRF4. is a member of the adhesion G protein-coupled receptor (aGPCR) family. These receptors are characterized by their large extracellular domains, which mediate cell-cell and cell-matrix interactions, and play roles in tissue development, immune response, and cellular signaling. GPR115 is a transmembrane protein implicated in various physiological processes, including cellular adhesion, proliferation, and differentiation. Its expression has been detected in tissues such as the lung, kidney, and skin, suggesting potential roles in organ development and homeostasis. However, the precise biological functions and signaling pathways of GPR115 remain incompletely understood.
Antibodies targeting GPR115 are critical tools for studying its localization, expression, and functional mechanisms. They enable detection of the receptor in experimental models (e.g., Western blot, immunohistochemistry) and facilitate research into its interactions with ligands or downstream effectors. Recent studies suggest GPR115 may be involved in disease contexts, such as cancer progression and inflammatory disorders, where its dysregulation correlates with pathological states. For example, elevated GPR115 expression has been observed in certain tumors, hinting at its potential as a biomarker or therapeutic target. Despite these advances, further research is needed to clarify its exact roles and therapeutic relevance. GPR115 antibodies thus serve as essential reagents for bridging molecular insights with translational applications.
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