| WB | 咨询技术 | Human,Monkey |
| IF | 咨询技术 | Human,Monkey |
| IHC | 1/100-1/300 | Human,Monkey |
| ICC | 1/200-1/1000 | Human,Monkey |
| FCM | 咨询技术 | Human,Monkey |
| Elisa | 1/40000 | Human,Monkey |
| Aliases | MRPS22; C3orf5; RPMS22; GK002; 28S ribosomal protein S22; mitochondrial; MRP-S22; S22mt |
| Entrez GeneID | 56945; |
| WB Predicted band size | 41kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Monkey |
| Immunogen | Synthesized peptide derived from the Internal region of human MRP-S22. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇涉及MRP-S22抗体的文献摘要信息(注：MRP-S22可能指线粒体核糖体蛋白S22.文献检索基于该假设)：
1. **文献名称**: "MRPS22 regulates energy metabolism and promotes tumor progression in breast cancer"
**作者**: Li X, et al.
**摘要**: 本研究利用MRPS22特异性抗体验证该蛋白在乳腺癌细胞中的高表达，发现其通过调控线粒体氧化磷酸化促进肿瘤能量代谢，并与患者不良预后相关。
2. **文献名称**: "Mitochondrial ribosomal protein S22 mutation causes developmental defects in zebrafish"
**作者**: Wang Y, et al.
**摘要**: 通过CRISPR技术构建斑马鱼MRPS22突变体，使用抗体验证蛋白表达缺失，发现其导致线粒体翻译缺陷及胚胎心脏发育异常，提示MRPS22在脊椎动物发育中的关键作用。
3. **文献名称**: "A novel MRPS22 antibody-based assay for detecting mitochondrial dysfunction in Parkinson's disease"
**作者**: Chen H, et al.
**摘要**: 开发了一种高特异性MRPS22抗体检测方法，发现帕金森患者脑组织中MRPS22表达显著降低，该指标可辅助评估线粒体功能损伤程度。
注：上述文献为示例性内容，实际研究中建议通过PubMed或Web of Science以"MRPS22 antibody"或"mitochondrial ribosomal protein S22"为关键词检索最新文献。若目标蛋白为其他类别(如多药耐药相关蛋白)，需重新明确蛋白分类后调整检索策略。
The MRP-S22 antibody targets the mitochondrial ribosomal protein S22 (MRPS22), a component of the small subunit (28S) of the mitochondrial ribosome. Mitochondrial ribosomes are essential for synthesizing proteins encoded by mitochondrial DNA, which are critical for oxidative phosphorylation (OXPHOS) and cellular energy production. MRPS22 plays a structural and functional role in mitochondrial translation, supporting the assembly and stability of the ribosome. Dysregulation of mitochondrial ribosomal proteins, including MRPS22. has been linked to mitochondrial disorders, cancer, and metabolic diseases.
The MRP-S22 antibody is widely used as a research tool to study mitochondrial protein synthesis, ribosome biogenesis, and mitochondrial dysfunction. It enables detection and quantification of MRPS22 in tissues or cell lines via techniques like Western blotting, immunofluorescence, or immunohistochemistry. Studies employing this antibody have explored MRPS22's role in cellular responses to stress, apoptosis, and metabolic adaptation. Additionally, altered MRPS22 expression has been observed in certain cancers, suggesting its potential as a biomarker or therapeutic target.
As mitochondrial research advances, the MRP-S22 antibody remains a key reagent for elucidating the molecular mechanisms underlying mitochondrial diseases and energy metabolism pathways.
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