| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | MRPL21; 39S ribosomal protein L21; mitochondrial; L21mt; MRP-L21 |
| Entrez GeneID | 219927; |
| WB Predicted band size | 23kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the Internal region of human MRP-L21. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于MRP-L21(Mitochondrial Ribosomal Protein L21)抗体的3篇参考文献，包含文献名称、作者及摘要概括：
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1. **文献名称**：*MRPL21 is a novel prognostic biomarker and therapeutic target in hepatocellular carcinoma*
**作者**：Li, X. et al.
**摘要**：本研究通过免疫组化及Western blot分析，验证了MRP-L21抗体在肝细胞癌(HCC)组织中的高表达，并发现其过表达与患者预后不良相关。机制研究表明，MRPL21通过调控线粒体呼吸链活性促进肿瘤细胞增殖。
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2. **文献名称**：*Mitochondrial ribosomal protein L21 modulates oxidative phosphorylation in mammalian cells*
**作者**：Smith, J.R. et al.
**摘要**：利用MRP-L21特异性抗体进行基因敲低实验，发现MRPL21缺失导致线粒体核糖体组装异常，进而抑制氧化磷酸化(OXPHOS)功能，提示其在能量代谢中的关键作用。
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3. **文献名称**：*A novel MRPL21 mutation causes mitochondrial encephalopathy with complex I deficiency*
**作者**：Gomez-Duran, A. et al.
**摘要**：通过全外显子测序和抗体验证，发现MRPL21基因突变导致线粒体脑病患者复合体I活性下降，研究强调了MRP-L21抗体在诊断线粒体疾病中的潜在价值。
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**备注**：以上文献为示例，实际文献需通过PubMed、Google Scholar等平台检索关键词“MRPL21 antibody”或“Mitochondrial Ribosomal Protein L21”获取。建议结合具体研究领域(如癌症、代谢疾病)进一步筛选。
The MRP-L21 antibody is a research tool designed to target Mitochondrial Ribosomal Protein L21 (MRP-L21), a component of the mitochondrial ribosome. Mitochondria, essential organelles for cellular energy production, rely on their own translation machinery to synthesize proteins critical for oxidative phosphorylation. MRP-L21 is part of the large subunit (39S) of the mitochondrial ribosome, which plays a structural or catalytic role in assembling the ribosome or facilitating protein synthesis within mitochondria. Dysregulation of mitochondrial ribosomal proteins, including MRP-L21. has been linked to metabolic disorders, neurodegenerative diseases, and cancer, as impaired mitochondrial translation disrupts energy metabolism and cellular homeostasis.
The MRP-L21 antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study protein expression, localization, and mitochondrial function in various biological contexts. Researchers employ it to investigate MRP-L21's role in mitochondrial disorders, aging, or cancer progression, where altered ribosomal protein levels may correlate with disease mechanisms. Specificity and validation are crucial, as cross-reactivity with cytosolic ribosomal proteins or homologs in other species can affect data interpretation. While MRP-L21's precise functional details remain under exploration, this antibody serves as a key reagent for elucidating mitochondrial biology and its implications in health and disease.
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