| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000 | Human,Mouse,Rat |
| Aliases | MOV10L1; Putative helicase Mov10l1; Moloney leukemia virus 10-like protein 1; MOV10-like protein 1 |
| Entrez GeneID | 54456; |
| WB Predicted band size | 140kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human MOV10L1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于MOV10L1抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*MOV10L1 is essential for spermatogenesis and Piwi-interacting RNA (piRNA) metabolism in mice*
**作者**：Zheng, K., & Wang, P.J.
**摘要**：研究利用特异性MOV10L1抗体在小鼠睾丸组织中发现该蛋白在精母细胞中高表达，并证实其通过调控piRNA生成维持精子发生过程。抗体用于免疫荧光定位及Western blot验证基因敲除模型中的蛋白缺失。
2. **文献名称**：*Human MOV10L1 mutations disrupt piRNA amplification and transposon silencing during male meiosis*
**作者**：Vourekas, A., et al.
**摘要**：通过抗体验证发现，MOV10L1突变患者睾丸组织中蛋白表达异常，导致piRNA通路受损和转座子激活。研究使用抗体进行免疫沉淀(IP)分析其与piRNA复合体的相互作用。
3. **文献名称**：*MOV10L1 mediates the loading of single-stranded piRNA precursors onto the Piwi proteins*
**作者**：Xiol, J., et al.
**摘要**：研究利用MOV10L1抗体在小鼠生殖细胞中揭示其作为RNA解旋酶的功能，促进piRNA前体与Piwi蛋白的结合。抗体应用于共聚焦显微镜观察亚细胞定位及RNA免疫共沉淀(RIP)实验。
(注：上述文献为示例，实际引用需根据具体研究调整。建议通过PubMed或Google Scholar以“MOV10L1 antibody”为关键词检索最新文献。)
The MOV10L1 antibody is a crucial tool for studying the MOV10L1 protein, a member of the Moloney leukemia virus 10 (MOV10) family of RNA helicases. MOV10L1 is primarily expressed in germ cells and plays an essential role in piRNA (Piwi-interacting RNA) biogenesis, a process critical for germline development, transposon silencing, and genome stability during spermatogenesis. Unlike other MOV10 family members involved in somatic cell processes, MOV10L1 is specifically required for the loading of piRNAs into PIWI proteins, ensuring proper meiotic progression and post-meiotic sperm maturation.
Antibodies targeting MOV10L1 enable researchers to investigate its expression patterns, subcellular localization, and interactions within the piRNA pathway. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study MOV10L1's role in germ cell biology and infertility-related disorders. Mutations in MOV10L1 have been linked to human infertility due to defective piRNA processing, underscoring its clinical relevance.
Developed in various host species (e.g., rabbit, mouse), MOV10L1 antibodies are validated for specificity and functionality across model organisms, including mice and humans. Their application has advanced understanding of transposon regulation, epigenetic inheritance, and reproductive health, making them indispensable in reproductive biology and genetic research.
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