Rabbit Polyclonal MRP-L24 Antibody

The MRP-L24 antibody is designed to detect mitochondrial ribosomal protein L24 (MRPL24), a component of the mitochondrial large ribosomal subunit (39S). Mitochondrial ribosomes are essential for synthesizing proteins encoded by mitochondrial DNA (mtDNA), which are critical subunits of the electron transport chain (ETC) complexes involved in oxidative phosphorylation (OXPHOS). MRPL24. encoded by the nuclear genome, is imported into mitochondria and assembled into the 39S subunit. It plays a role in maintaining mitochondrial ribosome stability and facilitating translation of mtDNA-encoded proteins. Dysregulation of MRPL24 has been linked to mitochondrial dysfunction, which is associated with metabolic disorders, neurodegenerative diseases, and cancer. Antibodies targeting MRPL24 are widely used in research to investigate mitochondrial protein synthesis, ribosome biogenesis, and energy metabolism. They enable detection via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in studies of mitochondrial dynamics, disease mechanisms, and therapeutic responses. Commercial MRP-L24 antibodies are typically validated for specificity using knockdown or knockout controls. However, cross-reactivity with cytoplasmic ribosomal proteins may occur due to evolutionary conservation, necessitating careful experimental validation. Research applications span cell biology, cancer metabolism, and mitochondrial disorders, underscoring its importance as a tool for exploring mitochondrial health and disease.