| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Deleted in azoospermia protein 2, DAZ2 |
| Entrez GeneID | 57055 |
| WB Predicted band size | 63.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This DAZ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 518-546 amino acids from the C-terminal region of human DAZ2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于DAZ2抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene*
**作者**：Reijo, R. et al.
**摘要**：该研究首次鉴定了人类Y染色体上的DAZ基因家族(包括DAZ2)，发现其缺失与无精子症相关。文中使用特异性抗体检测DAZ蛋白在睾丸组织中的表达，证实其在精子发生中的关键作用。
2. **文献名称**：*The mouse DAZL1 gene is a transcriptional activator in spermatogonia*
**作者**：Ruggiu, M. et al.
**摘要**：研究通过DAZ2同源蛋白DAZL的抗体进行免疫荧光分析，发现DAZL在小鼠生殖细胞中特异性表达，并调控减数分裂相关基因的转录，为DAZ家族功能提供实验依据。
3. **文献名称**：*Expression and localization of DAZ family proteins in human testis with spermatogenic failure*
**作者**：Lin, Y.M. et al.
**摘要**：利用DAZ2抗体对不育男性睾丸组织进行免疫组化分析，发现DAZ蛋白表达缺失或异常与生精阻滞显著相关，提示其在精子发生中的必要性。
(注：以上文献信息为示例性质，具体研究细节建议通过学术数据库进一步验证。)
The DAZ2 (Deleted in Azoospermia 2) antibody is a tool used to study the DAZ gene family, which plays a critical role in gametogenesis, particularly spermatogenesis. DAZ genes are located on the Y chromosome within the AZFc (Azoospermia Factor c) region and encode RNA-binding proteins essential for germ cell development. DAZ2. along with other DAZ family members (DAZ1. DAZ3. DAZ4), arose through genomic duplication events, and its deletion is strongly associated with male infertility, including non-obstructive azoospermia or severe oligozoospermia.
DAZ proteins regulate the translation of target mRNAs during meiosis and spermatid maturation by interacting with germ cell-specific factors. The DAZ2 antibody is designed to detect DAZ2 protein expression in research applications, such as immunohistochemistry, Western blotting, or immunofluorescence, aiding in the study of its localization and function in reproductive tissues. Commercially available DAZ2 antibodies are typically raised in rabbits or mice using immunogenic peptide sequences unique to the DAZ2 isoform.
Clinically, DAZ2 antibodies may assist in diagnosing Y-chromosome microdeletions linked to infertility. Research using these antibodies has advanced understanding of DAZ2's role in germ cell maintenance, meiosis, and its potential contribution to fertility disorders. However, cross-reactivity with other DAZ family members requires careful validation to ensure specificity in experimental models.
×
