| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Kinesin light chain 2, KLC 2, KLC2 |
| Entrez GeneID | 64837 |
| WB Predicted band size | 68.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KLC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-156 amino acids from the N-terminal region of human KLC2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于KLC2(N-term)抗体的3篇参考文献示例(注：文献为模拟生成，实际引用需核实)：
---
1. **文献名称**: *Kinesin Light Chain 2 (KLC2) regulates axonal transport through interaction with cargo adaptors*
**作者**: Smith A, et al.
**摘要**: 本研究使用KLC2(N-term)抗体进行免疫共沉淀(Co-IP)和免疫荧光(IF)，揭示了KLC2通过其N端结构域与多种囊泡蛋白结合，调控神经元轴突运输的分子机制。
2. **文献名称**: *Expression profiling of KLC2 in cancer progression and metastasis*
**作者**: Chen L, et al.
**摘要**: 通过Western blot和免疫组化(IHC)分析，利用KLC2(N-term)抗体发现KLC2在多种肿瘤组织中高表达，且其N端功能域缺失与肿瘤细胞迁移能力下降相关。
3. **文献名称**: *Structural insights into KLC2-Kinesin complex assembly*
**作者**: Gupta R, et al.
**摘要**: 通过X射线晶体学及抗体阻断实验，证实KLC2的N端区域是驱动蛋白(Kinesin)复合体组装的关键位点，研究为靶向运输通路的药物设计提供依据。
---
建议通过PubMed或Google Scholar以关键词“KLC2 N-terminal antibody”或“Kinesin Light Chain 2 antibody”进一步检索最新文献。
The KLC2 (N-term) antibody is a specific immunological tool designed to target the N-terminal region of kinesin light chain 2 (KLC2), a critical component of the kinesin-1 motor protein complex. Kinesin-1 facilitates intracellular anterograde transport by moving cargoes along microtubules, with KLC2 playing a key role in binding cargo adaptors and regulating kinesin activity. The KLC2 protein contains conserved domains, including N-terminal heptad repeats that mediate interactions with kinesin heavy chains (KHCs), and C-terminal tetratricopeptide repeats (TPRs) involved in cargo recognition.
This antibody is commonly used in research to investigate KLC2 expression, localization, and function in cellular processes such as organelle trafficking, neuronal transport, and cell division. It is particularly valuable in studies exploring pathologies linked to dysregulated intracellular transport, including neurodegenerative diseases (e.g., Alzheimer's, Charcot-Marie-Tooth) and cancer metastasis. By targeting the N-terminal region, the antibody allows specific detection of full-length KLC2 isoforms while avoiding cross-reactivity with truncated variants or homologous proteins like KLC1.
Validated applications typically include Western blotting, immunofluorescence, and immunohistochemistry. Researchers often use it to assess KLC2-protein interactions, monitor post-translational modifications, or evaluate tissue-specific expression patterns. Proper controls, such as siRNA knockdown samples, are recommended to confirm antibody specificity. Commercial versions are frequently raised in rabbits or mice, with reactivity spanning human, mouse, and rat homologs due to conserved N-terminal sequences.
×
