| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Pulmonary surfactant-associated protein A2, PSP-A, PSPA, SP-A, SP-A2, 35 kDa pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-5, SFTPA2, COLEC5, PSAP, SFTP1, SFTPA, SFTPA2B |
| Entrez GeneID | 729238 |
| WB Predicted band size | 26.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SFTPA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174-202 amino acids from the C-terminal region of human SFTPA2B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4篇与 **SFTPA2B抗体** 相关的文献示例(部分为模拟简化内容，实际文献需根据具体数据库检索验证)：
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1. **文献名称**: *SFTPA2 mutations in familial pulmonary fibrosis: clinical and functional characterization*
**作者**: Wang Y, et al.
**摘要**: 本研究分析了 **SFTPA2B基因突变** 在家族性肺纤维化中的作用，通过 **抗SFTPA2B抗体** 检测患者肺组织中的蛋白表达异常，发现突变导致蛋白错误折叠和肺泡上皮细胞损伤。
2. **文献名称**: *Autoantibodies against surfactant proteins in interstitial lung disease*
**作者**: Kishore U, et al.
**摘要**: 探讨间质性肺病(ILD)患者体内 **抗SFTPA2B自身抗体** 的存在及其病理意义，发现抗体水平与疾病严重程度相关，提示其可能作为诊断生物标志物。
3. **文献名称**: *Regulation of surfactant protein A2 expression by NF-κB in lung injury*
**作者**: García-Verdugo I, et al.
**摘要**: 利用 **SFTPA2B特异性抗体** 研究炎症因子对肺表面活性蛋白A2表达的调控机制，证实NF-κB通路在急性肺损伤中上调SFTPA2B表达。
4. **文献名称**: *Structural analysis of surfactant protein A2B oligomerization using monoclonal antibodies*
**作者**: Sorensen GL, et al.
**摘要**: 通过开发 **单克隆SFTPA2B抗体**，解析了肺表面活性蛋白A2B的寡聚化结构，揭示了其与先天免疫中病原体识别相关的功能域。
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**注意**：以上文献为示例性质，实际研究中建议通过 **PubMed** 或 **Google Scholar** 以关键词“SFTPA2B antibody”、“surfactant protein A2B”检索最新文献，并核对作者及摘要准确性。若研究较少，可扩展至“SFTPA2”(同基因家族)或“surfactant protein autoantibodies”相关领域。
The SFTPA2B antibody targets surfactant protein A2 (SP-A2), encoded by the SFTPA2 gene, a critical component of pulmonary surfactant. SP-A2. along with SP-A1. belongs to the collectin family and plays a key role in innate lung immunity by opsonizing pathogens, regulating surfactant homeostasis, and modulating inflammatory responses. These proteins are primarily expressed in alveolar type II cells and club cells, forming oligomers that bind microbial surfaces and interact with immune cells.
SFTPA2 mutations are linked to pulmonary fibrosis, lung cancer, and respiratory distress syndromes. The SFTPA2B antibody is used to study SP-A2 expression, localization, and function in both normal and diseased lung tissues. It aids in diagnosing SP-A2 deficiency and understanding its role in chronic lung diseases. Commercially available as monoclonal or polyclonal antibodies, it is validated for techniques like Western blot, immunohistochemistry, and ELISA. Research using this antibody has highlighted SP-A2's dual role in host defense and inflammation, suggesting therapeutic potential in targeting surfactant-associated disorders. Cross-reactivity varies by species, with most antibodies designed for human or murine applications.
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