| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Myosin-IIIb, MYO3B |
| Entrez GeneID | 140469 |
| WB Predicted band size | 151.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MYO3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1086-1116 amino acids from the C-terminal region of human MYO3B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MYO3B抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库验证)：
1. **文献名称**：*"MYO3B regulates cellular protrusions in pancreatic cancer metastasis"*
**作者**：Chen L, et al. (2021)
**摘要**：研究通过开发特异性MYO3B抗体，验证其在胰腺癌细胞中的高表达，并揭示其通过调控肌动蛋白重组促进肿瘤侵袭转移的机制。
2. **文献名称**：*"Characterization of MYO3B in auditory hair cell function using a novel monoclonal antibody"*
**作者**：Wang Y, et al. (2019)
**摘要**：报道一种高特异性抗MYO3B单克隆抗体的制备，通过免疫组化和小鼠模型证明MYO3B在内耳毛细胞纤毛形态维持中的关键作用。
3. **文献名称**：*"MYO3B antibody-based profiling identifies its role in colorectal cancer epithelial-mesenchymal transition"*
**作者**：Kim S, et al. (2020)
**摘要**：利用MYO3B抗体分析结直肠癌组织样本，发现其表达与EMT标志物相关，并通过体外实验证实其调控细胞迁移的功能。
4. **文献名称**：*"Development and validation of a MYO3B-specific polyclonal antibody for functional studies"*
**作者**：Garcia R, et al. (2018)
**摘要**：描述一种兔源多克隆MYO3B抗体的开发，经Western blot和免疫荧光验证其特异性，并用于探究MYO3B在细胞内的运输机制。
建议通过PubMed或Google Scholar以“MYO3B antibody”或“MYO3B function”为关键词检索最新文献获取详细信息。
MYO3B (myosin IIIB) is a member of the myosin superfamily, specifically categorized under class III myosins, which are actin-based motor proteins involved in intracellular transport and cytoskeletal organization. Unlike conventional myosins, MYO3B contains a unique N-terminal kinase domain fused to a motor domain, followed by a tail with multiple IQ motifs and a PDZ-binding motif. This structural complexity enables its dual functionality in both mechanoenzymatic activity and signal transduction. MYO3B is predominantly expressed in tissues such as the intestine, testis, and inner ear, where it plays roles in cellular processes like stereocilia maintenance, phototransduction, and vesicular trafficking.
Mutations or dysregulation of MYO3B have been linked to hearing loss and photoreceptor degeneration in model organisms, though its precise pathological mechanisms in humans remain under investigation. Recent studies also suggest its potential involvement in cancer progression, particularly colorectal cancer, where altered MYO3B expression correlates with tumor invasiveness.
MYO3B-specific antibodies are crucial tools for detecting protein localization, expression levels, and post-translational modifications in research. They facilitate studies on MYO3B’s interaction networks, regulatory pathways, and disease associations. Commercial antibodies are typically validated for applications like Western blotting, immunofluorescence, and immunohistochemistry, aiding in both basic research and clinical diagnostics. Ongoing research aims to elucidate MYO3B’s therapeutic potential as a biomarker or drug target.
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