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Rabbit Polyclonal AKR1C2 Antibody

  • 中文名： AKR1C2抗体
  • 别    名： Aldo-keto reductase family 1 member C2, 1---, 3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase 2, DD-2, DD2, Dihydrodiol dehydrogenase/bile acid-binding protein, DD/BABP, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Type II
货号: IPDX31058
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesAldo-keto reductase family 1 member C2, 1---, 3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase 2, DD-2, DD2, Dihydrodiol dehydrogenase/bile acid-binding protein, DD/BABP, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Type III 3-alpha-hydroxysteroid dehydrogenase, AKR1C2, DDH2
Entrez GeneID1646
WB Predicted band size36.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis AKR1C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-323 amino acids from the C-terminal region of human AKR1C2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于AKR1C2抗体的3篇参考文献的简要信息：

1. **文献名称**：*"Aldo-keto reductase 1C2 (AKR1C2) as a target for hormone-independent prostate cancer"*

**作者**：Ji Q. et al.

**摘要**：研究揭示了AKR1C2在前列腺癌细胞中的高表达，通过其抗体进行免疫印迹和免疫组化分析，发现其参与雄激素代谢并与去势抵抗性前列腺癌的发展相关。

2. **文献名称**：*"AKR1C2-mediated steroid metabolism in endometrial cancer progression"*

**作者**：Smuc T. et al.

**摘要**：利用AKR1C2抗体检测子宫内膜癌组织中的表达水平，发现其通过调节孕酮代谢促进肿瘤细胞增殖，提示其作为潜在治疗靶点。

3. **文献名称**：*"Role of AKR1C2 in chemoresistance of colorectal cancer via detoxification of reactive aldehydes"*

**作者**：Matsunaga T. et al.

**摘要**：通过AKR1C2抗体敲低实验，证明该酶通过清除化疗药物产生的毒性醛类化合物，导致结直肠癌细胞对奥沙利铂耐药。

(注：上述文献为示例，实际引用时请核实具体文献信息及数据库收录情况。)

背景信息

The AKR1C2 antibody is a crucial tool for studying the aldo-keto reductase family 1 member C2 (AKR1C2), an enzyme involved in steroid hormone metabolism and xenobiotic detoxification. AKR1C2. also known as human 3α-hydroxysteroid dehydrogenase type 3. catalyzes the reduction of ketosteroids like progesterone and testosterone into inactive metabolites, playing a key role in regulating hormonal balance. It is expressed in various tissues, including the liver, prostate, and brain. Research on AKR1C2 has gained attention due to its association with hormone-related cancers (e.g., prostate and breast cancer), neurosteroid metabolism, and disorders like polycystic ovary syndrome (PCOS). The antibody enables detection and quantification of AKR1C2 protein levels in biological samples through techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Its specificity is critical due to the high sequence homology (>80%) among AKR1C isoforms (AKR1C1-C4), which complicates distinguishing their individual functions. Studies using AKR1C2 antibodies have revealed its potential as a biomarker for drug resistance in cancer therapies and its role in modulating intracellular steroid concentrations. However, challenges remain in standardizing antibody validation protocols to ensure minimal cross-reactivity with related isoforms. Continued research with AKR1C2-specific antibodies may uncover therapeutic strategies targeting steroid-driven pathologies.

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