首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal DLK2 Antibody

  • 中文名: DLK2抗体
  • 别    名: Protein delta homolog 2, DLK-2, Epidermal growth factor-like protein 9, EGF-like protein 9, DLK2, EGFL9
货号: IPDX30441
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein delta homolog 2, DLK-2, Epidermal growth factor-like protein 9, EGF-like protein 9, DLK2, EGFL9
Entrez GeneID65989
WB Predicted band size40.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis DLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-380 amino acids from the C-terminal region of human DLK2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是3篇与DLK2抗体相关的文献示例(内容为模拟生成,仅供参考):

1. **文献名称**: "Characterization of a novel monoclonal antibody against human DLK2 for cancer biomarker studies"

**作者**: Tanaka H, et al.

**摘要**: 本研究开发了一种针对人DLK2蛋白的高特异性单克隆抗体,验证了其在免疫组化和Western blot中的应用,并发现DLK2在胰腺癌组织中高表达,提示其作为肿瘤标志物的潜力。

2. **文献名称**: "DLK2 modulates Notch signaling during neural stem cell differentiation"

**作者**: García-Alonso L, et al.

**摘要**: 通过DLK2抗体阻断实验,揭示了DLK2通过非经典Notch通路调控神经干细胞分化的分子机制,表明其在中枢神经系统发育中的关键作用。

3. **文献名称**: "Comparative analysis of DLK1 and DLK2 expression in hepatocellular carcinoma using immunohistochemistry"

**作者**: Wang Y, et al.

**摘要**: 利用商品化DLK2抗体对肝癌组织进行染色,发现DLK2与DLK1的表达呈负相关,且DLK2低表达与患者预后不良显著相关。

4. **文献名称**: "DLK2 as a therapeutic target in triple-negative breast cancer: Insights from antibody-based inhibition"

**作者**: Rodriguez-Barrueco R, et al.

**摘要**: 研究采用靶向DLK2的中和抗体,证明其可通过抑制Wnt/β-catenin通路减缓三阴性乳腺癌小鼠模型的肿瘤生长,为临床治疗提供新策略。

(注:以上文献为示例,实际文献需通过PubMed/Google Scholar等平台检索确认。)

背景信息

The DLK2 (Delta-like 2 homolog) antibody is a research tool targeting the DLK2 protein, a member of the EGF-like family of transmembrane proteins. DLK2 shares structural homology with DLK1. both containing epidermal growth factor (EGF) repeats and functioning as non-canonical ligands or modulators of the Notch signaling pathway. While less studied than DLK1. DLK2 is implicated in cellular differentiation, tissue development, and cancer progression. It is expressed in various tissues, including adipose, brain, and certain tumors, where it may regulate cell proliferation and apoptosis. Research suggests DLK2 interacts with Notch receptors or other pathways (e.g., Wnt) to influence stem cell maintenance and tumorigenesis. Antibodies against DLK2 are primarily used in experimental studies (e.g., Western blot, immunohistochemistry) to explore its expression patterns and functional roles. Emerging evidence links DLK2 overexpression to cancers (e.g., glioblastoma, breast cancer), positioning it as a potential biomarker or therapeutic target. However, its precise mechanisms and physiological relevance remain under investigation, necessitating further validation of antibody specificity and functional assays in diverse biological contexts.

客户数据及评论

折叠内容

大包装询价

×