| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Clathrin light chain A, Lca, CLTA |
| Entrez GeneID | 1211 |
| WB Predicted band size | 27.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CLTA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-127 amino acids from the Central region of human CLTA. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于CLTA(Clathrin Light Chain A)抗体的模拟参考文献示例(注：内容为虚构，仅作格式参考)：
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1. **文献名称**：*"CLTA Antibody-Based Detection of Altered Clathrin Dynamics in Neurodegenerative Models"*
**作者**：Chen, L. et al.
**摘要**：本研究利用特异性CLTA抗体，通过免疫荧光和Western blot技术，揭示了阿尔茨海默病模型中网格蛋白轻链A的异常聚集现象，表明其与神经元内吞功能障碍的相关性。
2. **文献名称**：*"Autoantibodies Against CLTA in Autoimmune Hepatitis: A Novel Diagnostic Biomarker"*
**作者**：Rodriguez, S. et al.
**摘要**：通过ELISA筛查发现，自身免疫性肝炎患者血清中存在高水平的CLTA自身抗体，提示CLTA可能成为该类疾病的新型血清学标志物，并参与病理机制。
3. **文献名称**：*"Development of a High-Affinity Monoclonal Antibody for CLTA with Applications in Cancer Research"*
**作者**：Wang, Y. et al.
**摘要**：报道了一种新型CLTA单克隆抗体的开发，验证了其在流式细胞术和免疫组化中的高特异性，并证明CLTA在乳腺癌细胞膜转运中的表达上调与化疗耐药性相关。
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**注**：以上文献为示例，实际研究中请通过PubMed、Google Scholar等平台检索真实发表的论文。若需具体文献协助，可提供更详细的研究方向以便进一步筛选。
**Background of CLTA Antibody**
CLTA (Clathrin Light Chain A) antibodies target a key component of clathrin, a protein critical for intracellular vesicle formation and membrane trafficking. Clathrin consists of three heavy chains (CHC) and three light chains (CLC), with CLTA and CLC-B (Clathrin Light Chain B) being the two light chain variants. CLTA plays a role in regulating clathrin-coated vesicle assembly, endocytosis, and synaptic vesicle recycling, influencing processes like nutrient uptake, signal transduction, and neurotransmitter release.
CLTA antibodies are widely used in research to study clathrin's localization, expression, and function in cellular pathways. They help investigate clathrin-mediated endocytosis (CME) defects linked to diseases such as cancer, neurological disorders, and viral infections (e.g., influenza, HIV). For example, altered CLTA expression has been observed in certain cancers, suggesting its role in tumor progression.
These antibodies are essential tools in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Their specificity allows differentiation between CLTA and CLC-B isoforms, aiding in isoform-specific functional studies. Additionally, CLTA antibodies contribute to understanding clathrin's non-canonical roles, such as mitotic spindle regulation or actin cytoskeleton organization.
Overall, CLTA antibodies provide insights into fundamental cellular mechanisms and disease pathologies, making them valuable in both basic and translational research.
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