| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Peroxisomal membrane protein 11A, HsPEX11p, 28 kDa peroxisomal integral membrane protein, PMP28, Peroxin-11A, Peroxisomal biogenesis factor 11A, Protein PEX11 homolog alpha, PEX11-alpha, PEX11A, PEX11 |
| Entrez GeneID | 8800 |
| WB Predicted band size | 28.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PEX11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PEX11A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PEX11A (N-term)抗体的3篇参考文献示例(注：文献为虚构示例，仅用于演示格式)：
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1. **文献名称**: *PEX11A regulates peroxisome membrane dynamics through interaction with mitochondrial fission factors*
**作者**: Smith J, et al. (2020)
**摘要**: 本研究利用PEX11A (N-term)抗体进行免疫荧光和Western blot，揭示了PEX11A在过氧化物酶体与线粒体动态互作中的作用。结果显示，PEX11A的N端结构域对其招募至过氧化物酶体膜及调控膜延伸至关重要。
2. **文献名称**: *Functional characterization of PEX11A isoforms in peroxisome biogenesis*
**作者**: Lee S, et al. (2018)
**摘要**: 通过PEX11A (N-term)抗体的免疫共沉淀实验，作者发现PEX11A存在两种剪切变体，其N端差异影响与PEX19的结合能力，进而调控过氧化物酶体的早期组装过程。
3. **文献名称**: *PEX11A deficiency disrupts lipid metabolism in a zebrafish model*
**作者**: Zhang Y, et al. (2021)
**摘要**: 该研究使用PEX11A (N-term)抗体进行斑马鱼组织的免疫组化分析，证实PEX11A缺失导致过氧化物酶体功能异常，并引发脂肪酸氧化障碍，为相关代谢疾病提供了机制解释。
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**说明**：
- 上述文献为示例，实际引用需以真实发表研究为准。
- 若需真实文献，建议在PubMed等数据库检索关键词“PEX11A antibody N-terminal”或结合具体研究背景筛选。
The PEX11A (N-term) antibody is a tool used to detect the N-terminal region of peroxisomal membrane protein 11A (PEX11A), a key regulator of peroxisome proliferation and morphology. PEX11A belongs to the PEX11 protein family (α, β, γ), which facilitates peroxisome membrane elongation, division, and maintenance. It is embedded in the peroxisomal membrane and interacts with other peroxins (e.g., PEX19. dynamin-like proteins) to mediate membrane remodeling. Dysfunction of PEX11A is linked to peroxisome biogenesis disorders (e.g., Zellweger spectrum disorders) and metabolic disruptions.
The N-terminal-specific antibody targets epitopes in the cytoplasmic-facing region of PEX11A, enabling applications like Western blotting, immunofluorescence, and immunohistochemistry to study protein expression, localization, and interactions. It helps researchers investigate peroxisome dynamics, metabolic pathways (e.g., fatty acid β-oxidation), and disease mechanisms. Validation typically includes testing in knockout models or siRNA-treated cells to confirm specificity. Commercial versions are often raised in rabbits or mice, with reactivity across human, mouse, and rat samples. Its use advances studies in cell biology, neurology, and metabolic disease research.
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