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Rabbit Polyclonal CYP2J2(N-term) Antibody

  • 中文名： CYP2J2 (N-term)抗体
  • 别    名： Cytochrome P450 2J2, Arachidonic acid epoxygenase, CYPIIJ2, CYP2J2
货号: IPDX30436
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCytochrome P450 2J2, Arachidonic acid epoxygenase, CYPIIJ2, CYP2J2
Entrez GeneID1573
WB Predicted band size57.6kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CYP2J2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-124 amino acids from the N-terminal region of human CYP2J2.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于CYP2J2(N-term)抗体的3篇参考文献及其简要摘要：

1. **文献名称**：*"CYP2J2 Epoxygenase Expression in Human Tumors: Potential Role in Cancer Progression"*

**作者**：Xu, M. et al.

**摘要**：研究通过Western blot和免疫组化(使用N端特异性CYP2J2抗体)分析了多种肿瘤组织中CYP2J2的表达，发现其高表达与肿瘤血管生成和转移相关，提示其在癌症进展中的作用。

2. **文献名称**：*"Cytochrome P450 2J2 Promotes Tumor Angiogenesis via Epoxyeicosatrienoic Acid-Dependent Pathways"*

**作者**：Chen, J.K. et al.

**摘要**：利用N端CYP2J2抗体检测细胞和动物模型中蛋白表达，证明CYP2J2通过代谢花生四烯酸生成EETs促进肿瘤血管生成，为抗血管治疗提供新靶点。

3. **文献名称**：*"Tissue-Specific Distribution and Regulation of Cytochrome P450 2J2 in the Heart"*

**作者**：Wu, S. et al.

**摘要**：通过免疫荧光和免疫沉淀(N端抗体)研究CYP2J2在心脏组织中的定位，发现其在心肌细胞线粒体膜高表达，并受缺氧调控，可能影响心脏保护性脂质代谢。

注：以上为示例性内容，实际文献需通过学术数据库(如PubMed)检索确认。建议使用关键词“CYP2J2 antibody N-terminal”或结合具体研究领域(如癌症、心血管)筛选文献。

背景信息

The CYP2J2 (N-term) antibody is a specialized tool designed to detect the N-terminal region of the cytochrome P450 family 2 subfamily J member 2 (CYP2J2), a membrane-bound enzyme primarily expressed in cardiovascular tissues, liver, and gastrointestinal organs. CYP2J2 plays a critical role in metabolizing endogenous compounds, including arachidonic acid, into bioactive epoxyeicosatrienoic acids (EETs), which regulate vascular tone, inflammation, and cellular proliferation. Its involvement in cardiovascular homeostasis and disease mechanisms, such as hypertension and atherosclerosis, has driven research interest. The N-terminal-specific antibody targets epitopes within the enzyme’s initial ~50 amino acid residues, enabling selective identification of CYP2J2 isoforms while minimizing cross-reactivity with other P450 family members. This antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study protein expression, localization, and regulatory changes in disease models or under pharmacological interventions. Studies utilizing this reagent have linked CYP2J2 overexpression to pathological conditions, including cardiac hypertrophy, cancer progression, and metabolic disorders, highlighting its potential as a therapeutic target or biomarker. Validation via knockout controls or siRNA knockdown is recommended to confirm specificity, as endogenous expression levels can vary across tissues.

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