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Rabbit Monoclonal ELMO1 Antibody

  • 中文名: ELMO1抗体
  • 别    名: CED12; Ced12 homolog 1; ELMO 1;;ELMO1
货号: IPDX18106
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCED12; Ced12 homolog 1; ELMO 1;;ELMO1
WB Predicted band size84 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human ELMO1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于ELMO1抗体的3篇参考文献,按文献名称、作者和摘要内容简要概括:

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1. **文献名称**:*ELMO1 regulates autophagy induction through interaction with ATG5 in breast cancer metastasis*

**作者**:Kim H, et al.

**摘要**:该研究利用ELMO1特异性抗体(兔单克隆抗体)发现ELMO1通过与自噬相关蛋白ATG5的相互作用促进乳腺癌细胞的自噬和转移,揭示了ELMO1-ATG5通路在肿瘤侵袭中的关键作用。

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2. **文献名称**:*Genetic deletion of ELMO1 attenuates diabetic nephropathy by reducing inflammation and fibrosis*

**作者**:Shi Y, et al.

**摘要**:通过ELMO1敲除小鼠模型及ELMO1抗体(小鼠多克隆抗体)的免疫组织化学分析,证明ELMO1缺失可减轻糖尿病肾病中的炎症反应和纤维化,提示其作为治疗靶点的潜力。

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3. **文献名称**:*ELMO1 interacts with Dock180 to promote Rac activation and cell migration in response to growth factor signaling*

**作者**:Gumienny TL, et al.

**摘要**:该研究使用ELMO1抗体(兔多克隆抗体)进行免疫共沉淀实验,证实ELMO1与Dock180蛋白结合形成复合物,激活Rac信号通路,从而调控生长因子诱导的细胞迁移。

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如需具体文献来源或补充更多条目,可进一步提供数据库检索关键词(如PMID或DOI)。

背景信息

The ELMO1 (Engulfment and Cell Motility Protein 1) antibody is a tool used to study the ELMO1 protein, a critical regulator of cytoskeletal dynamics and cellular processes like phagocytosis, cell migration, and adhesion. ELMO1 interacts with Dock180 to form an evolutionarily conserved complex that activates Rac GTPases, promoting actin reorganization and signaling pathways involved in embryogenesis, immunity, and cancer metastasis. ELMO1's role in disease has garnered significant interest; genetic studies link ELMO1 variants to diabetic nephropathy, inflammatory disorders, and cancer progression. For instance, elevated ELMO1 expression correlates with tumor invasion and poor prognosis in cancers like glioblastoma and colorectal carcinoma. Researchers use ELMO1 antibodies in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression, localization, and interactions in cellular and tissue samples. These studies help elucidate ELMO1's mechanistic contributions to pathological processes, including epithelial-mesenchymal transition (EMT) and inflammatory responses. Commercially available ELMO1 antibodies are typically validated for specificity and application in diverse models, aiding translational research aimed at targeting ELMO1-related pathways for therapeutic intervention.

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