| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | OT R; OTR; OTR1; OXT R; Oxtr;;Oxytocin receptor |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Oxytocin receptor |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Oxytocin受体抗体的3篇参考文献及其摘要概述：
1. **"Characterization of a monoclonal antibody to the rat oxytocin receptor"**
- 作者：Qianhui Yu等
- 摘要：该文献报道了一种针对大鼠催产素受体(OTR)的单克隆抗体的开发与验证。作者通过免疫组化和Western blot实验，证明该抗体能特异性识别OTR蛋白，并成功用于检测中枢神经系统及外周组织中的OTR分布，为后续功能研究提供了工具。
2. **"Oxytocin receptor antibody generation and validation in autism spectrum disorder research"**
- 作者：Karen Parker等
- 摘要：研究团队开发了一种高特异性的OTR抗体，用于探索自闭症患者脑组织中OTR的表达异常。通过免疫荧光和流式细胞术验证了抗体可靠性，并发现患者前额叶皮层的OTR水平显著降低，提示其与社交行为缺陷相关。
3. **"Functional blocking of oxytocin receptors using a novel antibody inhibits uterine contractions in preterm labor models"**
- 作者：Takashi Kimura等
- 摘要：该研究设计了一种靶向OTR胞外域的抗体，成功抑制了体外培养的人子宫平滑肌细胞收缩活性。动物实验表明，该抗体可延迟早产模型小鼠的分娩时间，为开发新型早产治疗策略提供了实验依据。
注：以上文献名为示例性虚构内容，实际研究中需检索真实数据库(如PubMed)获取准确信息。
The oxytocin receptor (OTR) is a G protein-coupled receptor (GPCR) that mediates the effects of oxytocin, a neuropeptide involved in social bonding, childbirth, lactation, and emotional regulation. OTR antibodies are essential tools for studying the distribution, expression, and function of these receptors in tissues and cell models. They are widely used in techniques like immunohistochemistry (IHC), western blotting, and immunofluorescence to visualize OTR localization in the brain, uterus, mammary glands, and other organs.
Research on OTR antibodies has advanced understanding of oxytocin's role in behaviors (e.g., maternal care, trust) and pathologies, including autism spectrum disorders, anxiety, and metastatic cancers. Commercially available OTR antibodies vary in specificity, often targeting extracellular or intracellular receptor domains. However, cross-reactivity with vasopressin receptors (structurally similar to OTR) remains a validation challenge, emphasizing the need for rigorous controls.
Recent studies also explore OTR's therapeutic potential, such as in managing social dysfunction or enhancing drug delivery in cancer. Species reactivity (human, rodent, etc.) and tissue-specific isoforms further complicate antibody selection. Despite these challenges, well-validated OTR antibodies remain critical for unraveling oxytocin-mediated pathways and their translational applications in neuroscience, endocrinology, and oncology.
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