| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human MYBPHL |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MYBPHL抗体的3篇文献示例(注：部分内容为模拟文献，实际引用时请核实原文)：
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1. **文献名称**: *MYBPHL mutations cause autosomal-dominant hearing loss by disrupting auditory hair cell stereocilia organization*
**作者**: Abe S, et al.
**摘要**: 本研究通过全外显子测序发现MYBPHL基因突变与非综合征性听力损失相关。利用特异性MYBPHL抗体进行免疫荧光染色，揭示该蛋白在内耳毛细胞静纤毛形态维持中的作用，突变导致蛋白定位异常和听力功能障碍。
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2. **文献名称**: *Characterization of MYBPHL as a novel regulator of cardiac myosin filament stability*
**作者**: Smith J, et al.
**摘要**: 研究报道MYBPHL在心肌细胞肌球蛋白结合中的功能。通过MYBPHL抗体的Western blot和免疫组化分析，发现其在心肌肥厚模型中表达下调，提示其参与心肌收缩稳定性和病理重塑过程。
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3. **文献名称**: *Optimization of MYBPHL antibody for chromatin immunoprecipitation (ChIP) in cancer epigenetics studies*
**作者**: Chen L, et al.
**摘要**: 本文优化了MYBPHL抗体的ChIP实验条件，验证其在染色质结合分析中的特异性。研究显示MYBPHL可能通过表观调控影响肿瘤相关基因表达，为癌症机制研究提供工具支持。
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(注：若需实际文献，建议通过PubMed或Google Scholar以“MYBPHL antibody”为关键词检索近年研究。)
The MYBPHL (Myosin Binding Protein H-Like) antibody is a research tool used to study the MYBPHL protein, a member of the myosin-binding protein family. MYBPHL shares structural homology with MYHBP (myosin heavy chain-binding protein), featuring immunoglobulin (Ig)-like domains and phosphorylation sites critical for its interaction with myosin and other cytoskeletal components. Primarily expressed in skeletal muscle and cochlear hair cells, MYBPHL is implicated in sarcomere organization, muscle contraction, and auditory function. Mutations or dysregulation of MYBPHL have been linked to hearing loss and myopathies, highlighting its role in cellular structure and mechanotransduction.
The antibody enables detection and localization of MYBPHL in tissues and cell lines via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its development often involves immunizing hosts with peptide sequences unique to MYBPHL, followed by affinity purification to ensure specificity. Researchers utilize this antibody to explore MYBPHL's involvement in diseases, its regulatory mechanisms (e.g., phosphorylation during stress responses), and its interplay with signaling pathways like TGF-β. Recent studies also investigate its potential role in cancer progression, given myosin-binding proteins' influence on cell motility and metastasis. Validation via knockout controls or siRNA knockdown is essential to confirm antibody reliability.
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