| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CHK; CTK |
| Entrez GeneID | 4145 |
| clone | 9D7 |
| WB Predicted band size | 56kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human MATK expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是3-4条关于MATK抗体的模拟参考文献(基于公开研究背景的概括，非真实文献)：
1. **"MATK regulates T-cell receptor signaling through phosphorylation of Lck"**
- **作者**: Hua Gu, et al.
- **摘要**: 研究MATK在T细胞受体信号传导中的作用，发现其通过磷酸化Lck激酶调控T细胞活化，并开发了特异性MATK抗体用于Western blot检测，验证其在免疫细胞中的表达模式。
2. **"Expression and functional analysis of MATK in breast cancer progression"**
- **作者**: Koji Sakamoto, et al.
- **摘要**: 分析MATK在乳腺癌组织中的表达水平，使用商业化MATK抗体进行免疫组化实验，发现高表达MATK与患者预后不良相关，提示其可能作为癌症治疗的潜在靶点。
3. **"MATK antibody-based inhibition suppresses autoimmune arthritis in murine models"**
- **作者**: Emily J. Park, et al.
- **摘要**: 利用单克隆MATK抗体阻断MATK活性，在类风湿性关节炎小鼠模型中观察到炎症缓解和关节损伤减少，表明MATK在自身免疫反应中的关键作用。
4. **"Development of a high-affinity MATK monoclonal antibody for diagnostic applications"**
- **作者**: Richard R. Ribaudo, et al.
- **摘要**: 报道一种新型高特异性MATK单克隆抗体的开发，通过噬菌体展示技术筛选，验证其在流式细胞术和免疫荧光中的灵敏度和可靠性，适用于临床样本检测。
**注意**：以上文献为示例性质，实际引用需通过PubMed、Google Scholar等平台检索真实发表的研究。
MATK (Megakaryocyte-associated tyrosine kinase) antibody is a research tool targeting the MATK protein, a non-receptor tyrosine kinase encoded by the *MATK* gene. Initially identified in megakaryocytes and hematopoietic cells, MATK shares structural homology with the CSK (C-terminal Src kinase) family and regulates Src-family kinases (SFKs) by phosphorylating their inhibitory C-terminal tyrosine residues. This activity modulates cellular signaling pathways involved in proliferation, differentiation, and immune responses. Dysregulation of MATK has been implicated in cancers, including leukemia and lymphoma, as well as autoimmune disorders, making it a potential biomarker or therapeutic target.
MATK antibodies are widely used in immunoblotting, immunohistochemistry, and flow cytometry to study MATK expression, localization, and function in physiological and pathological contexts. They help elucidate its role in SFK-mediated signaling cascades and interactions with cytoskeletal proteins or adaptors. Recent studies also explore MATK's involvement in neuronal development and immune regulation. Commercial MATK antibodies are typically validated for specificity against recombinant or endogenous proteins across human, mouse, or rat models. However, variability in antibody performance necessitates careful validation for experimental reproducibility. Ongoing research aims to clarify MATK's dual roles in tumor suppression and oncogenesis, highlighting its therapeutic relevance.
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