Rabbit Polyclonal TAB1 Antibody

The TAB1 (TAK1-binding protein 1) antibody is a key tool for studying the TAB1 protein, a critical adaptor molecule in cellular signaling pathways. TAB1 interacts with TAK1 (transforming growth factor-β-activated kinase 1) to form a complex that activates downstream signaling cascades, including NF-κB and MAPK pathways, which regulate inflammation, immune responses, and stress responses. This interaction is essential for mediating signals from receptors like IL-1R, TNF-R, and Toll-like receptors. TAB1 antibodies are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to detect TAB1 expression, localization, and protein-protein interactions in various biological samples. Researchers employ these antibodies to investigate TAB1's role in diseases, including cancer, neurodegenerative disorders, and autoimmune conditions, where dysregulated TAK1-TAB1 signaling is implicated. Most TAB1 antibodies are raised in hosts like rabbits or mice, targeting specific epitopes (e.g., human TAB1 residues 300-400). Validation includes testing for specificity via knockout controls or siRNA knockdown. Commercial TAB1 antibodies often come with data demonstrating reactivity across species (human, mouse, rat) and applications. Their utility extends to both basic research and drug discovery, particularly in studying pathways involved in inflammation and apoptosis.