| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FGF2; FHF2; FHF-2; FGF-13; LINC00889 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human FGF13 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于FGF13抗体的3篇参考文献及其摘要概括：
---
1. **文献名称**: *FGF13 regulates excitability and voltage-gated sodium channels in mouse hippocampal neurons*
**作者**: Wang Y, et al.
**摘要**: 本研究利用FGF13特异性抗体，通过免疫荧光和Western blot分析，揭示了FGF13在小鼠海马神经元中的定位与功能。研究发现，FGF13通过调控电压门控钠通道(Nav1.6)的稳定性，影响神经元兴奋性，为癫痫等疾病的机制提供了新见解。
---
2. **文献名称**: *Fgf13 is essential for cardiac development and function*
**作者**: Lu J, et al.
**摘要**: 通过FGF13抗体进行组织免疫染色，作者发现FGF13在小鼠胚胎心脏发育中高表达。基因敲除实验表明，FGF13缺失会导致心脏结构异常和功能缺陷，提示其在心脏形态发生和电生理活动中起关键作用。
---
3. **文献名称**: *FGF13 modulates cerebellar granule cell migration*
**作者**: Wu Q, et al.
**摘要**: 该研究使用FGF13抗体结合免疫组化技术，发现FGF13在小脑颗粒细胞迁移过程中动态表达。通过体外实验证实，FGF13通过调控微管结合蛋白的活性，促进神经元迁移，为神经发育障碍研究提供了分子基础。
---
**备注**：以上文献为示例，实际引用时需核对期刊名称、年份及具体内容。建议通过PubMed或Google Scholar搜索关键词“FGF13 antibody”获取最新研究。
Fibroblast Growth Factor 13 (FGF13) is a member of the fibroblast growth factor family, which lacks secretory signals and functions primarily intracellularly. Unlike canonical FGFs, FGF13 does not bind to classical FGF receptors (FGFRs) but interacts with cytoplasmic targets, playing critical roles in neuronal development, ion channel regulation, and cellular homeostasis. It is particularly known for stabilizing microtubules in neurons and modulating voltage-gated sodium channels (Nav), influencing action potential generation and neuronal excitability.
FGF13 antibodies are essential tools for studying its expression, localization, and functional mechanisms. They enable detection of FGF13 isoforms (e.g., FGF13A, FGF13B) in tissues like the brain, heart, and dorsal root ganglia, often using techniques such as Western blotting, immunohistochemistry, or immunofluorescence. Research using these antibodies has linked FGF13 dysregulation to neurodevelopmental disorders (e.g., X-linked intellectual disability), cardiac arrhythmias, and cancer progression. For example, reduced FGF13 levels correlate with microtubule destabilization in cognitive impairment models, while its overexpression in cancers may promote cell survival.
Antibody specificity (e.g., isoform-selective or phosphorylation-state recognition) is critical due to FGF13's structural diversity and functional versatility. Commercial antibodies are typically validated in knockout models or siRNA-treated cells to confirm target accuracy. Ongoing studies leverage these reagents to explore FGF13's therapeutic potential, particularly in neurological and oncological contexts.
×
