关键信息
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基因名
CD6
- 应用
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别名
CD6 antigen; Cd6
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种属
Mouse
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q91WN5
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表达区间
L18-G396
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氨基酸序列
LPSPAPSGQHKNGTIPNMTLDLEERLGIRLVNGSSRCSGSVKVLLESWEPVCAAHWNRAATEAVCKALNCGDSGKVTYLMPPTSELPPGATSGNTSSAGNTTWARAPTERCRGANWQFCKVQDQECSSDRRLVWVTCAENQAVRLVDGSSRCAGRVEMLEHGEWGTVCDDTWDLQDAHVVCKQLKCGWAVKALAGLHFTPGQGPIHRDQVNCSGTEAYLWDCPGRPGDQYCGHKEDAGVVCSEHQSWRLTGGIDSCEGQVEVYFRGVWSTVCDSEWYPSEAKVLCRSLGCGSAVARPRGLPHSLDGRMYYSCKGQEPALSTCSWRFNNSNLCSQSRAARVVCSGSQRHLNLSTSEVPSRVPVTIESSVPVSVKDKDSQG
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蛋白长度
Partial
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分子量
60-90 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CD6 is a significant receptor primarily expressed on T cells and plays a crucial role in cell activation and immune response modulation. Research on CD6 has gained momentum due to its involvement in various autoimmune diseases and malignancies, making it a potential target for immunotherapy. The protein's structure and function have drawn interest, as understanding its interactions can reveal mechanisms behind T cell regulation and differentiation. CD6's engagement with its primary ligand, activated leukocyte cell adhesion molecule (ALCAM), contributes to the formation of immunological synapses, enhancing T cell responses. Moreover, studies have indicated that manipulating CD6 signaling could provide therapeutic strategies for treating conditions such as multiple sclerosis and cancer. As researchers explore CD6’s molecular pathways, the development of recombinant CD6 proteins has become essential for investigating their functional implications and therapeutic potential. This includes engineering soluble forms of CD6 for use in experimental assays, which can facilitate the evaluation of its role in cell signaling and immune system dynamics. The comprehensive understanding of CD6 and its signaling pathways could lead to novel interventions in immunotherapy, enhancing the efficacy of cancer treatments and improving outcomes in autoimmune disorders. Thus, ongoing research into CD6 recombinant proteins is pivotal for advancing therapeutic approaches in immunology and oncology.
