| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DHRS10; SDR47C1; retSDR3 |
| WB Predicted band size | 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human HSD17B14 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HSD17B14抗体的3篇示例性参考文献(注：内容为示例，实际文献需通过学术数据库验证)：
1. **文献名称**：*Characterization of HSD17B14 Antibody for Detection of 17β-Hydroxysteroid Dehydrogenase Type 14 in Human Tissues*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种特异性HSD17B14多克隆抗体，通过Western blot和免疫组化验证其在多种人组织中的表达模式。结果显示HSD17B14在肝脏和前列腺组织中高表达，提示其在类固醇代谢中的潜在作用。
2. **文献名称**：*HSD17B14 Expression in Breast Cancer: Association with Hormone Receptor Status*
**作者**：Zhang Y, et al.
**摘要**：利用抗HSD17B14抗体对乳腺癌组织进行免疫组化分析，发现该酶在雌激素受体阳性(ER+)肿瘤中显著上调，提示其可能参与局部雌激素生物合成，影响肿瘤进展。
3. **文献名称**：*Functional Analysis of HSD17B14 Using CRISPR/Cas9 and Specific Antibody Validation*
**作者**：Johnson R, et al.
**摘要**：通过CRISPR/Cas9敲低HSD17B14基因，结合特异性抗体检测蛋白表达变化，发现HSD17B14缺失会降低细胞中雄烯二酮向睾酮的转化率，表明其在性激素代谢中的关键作用。
建议通过PubMed或Google Scholar搜索**HSD17B14 antibody**或**17β-HSD14**获取最新研究。
The HSD17B14 antibody is a research tool designed to detect and analyze the 17β-hydroxysteroid dehydrogenase type 14 (HSD17B14) protein, a member of the 17β-HSD enzyme family. These enzymes play critical roles in steroid hormone metabolism, particularly in the regulation of active and inactive forms of sex hormones (e.g., estrogens, androgens) and other steroids. HSD17B14 is implicated in converting estrone to estradiol and may influence hormonal balance in tissues. Structurally, it contains a conserved short-chain dehydrogenase/reductase (SDR) domain, typical of this enzyme family.
HSD17B14 antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study the protein's expression, localization, and function in cellular or tissue samples. Research suggests HSD17B14 may have roles in hormone-dependent cancers (e.g., breast, prostate) and metabolic disorders, though its precise biological mechanisms remain under investigation. Antibodies against HSD17B14 help researchers explore its potential as a biomarker or therapeutic target. Commercial antibodies are often validated for specificity across human and model organism samples. Ongoing studies aim to clarify its physiological impact, interactions, and relevance to diseases, driving demand for reliable detection tools in both basic and translational research.
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