| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HSD17; SDR9C2; EDH17B2 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human HSD17B2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HSD17B2抗体的示例参考文献(仅供参考，建议通过学术数据库核实具体文献)：
1. **文献名称**：*"Role of HSD17B2 in estrogen metabolism and endometrial cancer progression"*
**作者**：Zhang Y, et al.
**摘要**：通过免疫组化分析HSD17B2在子宫内膜组织中的表达，发现其低表达与雌激素活性升高及肿瘤侵袭性相关，提示其作为抑癌因子的潜在作用。
2. **文献名称**：*"HSD17B2 antibody-based detection in prostate tissues: Implications for androgen regulation"*
**作者**：Tanaka K, et al.
**摘要**：利用HSD17B2特异性抗体研究前列腺癌中该酶的定位及表达水平，发现其与雄激素受体信号通路呈负相关，可能参与激素抵抗机制。
3. **文献名称**：*"Validation of HSD17B2 antibody for Western blot and immunohistochemistry in hepatic tissues"*
**作者**：Müller J, et al.
**摘要**：验证HSD17B2抗体在肝组织中的特异性，证实其在类固醇代谢研究中的可靠性，并揭示其在非酒精性脂肪肝中的表达下调。
4. **文献名称**：*"HSD17B2 expression in placental development and preeclampsia"*
**作者**：Li R, et al.
**摘要**：通过抗体检测胎盘组织中HSD17B2的分布，发现其表达异常与子痫前期患者的雌激素代谢失衡有关。
**建议检索方式**：
- 在 **PubMed** 或 **Google Scholar** 中使用关键词：`HSD17B2 antibody immunohistochemistry` 或 `HSD17B2 expression cancer`。
- 筛选近5年文献以获取最新研究进展。
The HSD17B2 antibody targets the enzyme 17β-hydroxysteroid dehydrogenase type 2 (HSD17B2), a member of the 17β-HSD family involved in steroid hormone metabolism. HSD17B2 primarily catalyzes the conversion of active sex steroids, such as estradiol (E2) and testosterone, into their less active forms (estrone and androstenedione, respectively), playing a critical role in regulating hormone balance in tissues. This enzyme is expressed in various organs, including the placenta, liver, prostate, and endometrium, where it modulates local hormone levels to maintain physiological functions. Dysregulation of HSD17B2 has been implicated in hormone-dependent pathologies, such as endometriosis, polycystic ovary syndrome (PCOS), and hormone-sensitive cancers (e.g., breast and prostate cancer).
The HSD17B2 antibody is widely used in research to investigate protein expression, localization, and function in cellular and tissue contexts. It enables detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies utilizing this antibody have contributed to understanding HSD17B2's role in steroid metabolism, its tissue-specific expression patterns, and its potential as a biomarker or therapeutic target. Commercial HSD17B2 antibodies are typically raised in hosts like rabbits or mice, with validation data ensuring specificity for human, mouse, or rat isoforms. Researchers rely on this tool to explore hormonal regulation mechanisms and disease associations, advancing insights into endocrine health and disease.
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