| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HL; HTGL; LIPH; HDLCQ12 |
| WB Predicted band size | 56 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human LIPC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于LIPC(肝脂酶)抗体的示例参考文献(注：以下内容为模拟示例，非真实文献)：
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1. **文献名称**: *"Hepatic Lipase Expression and Genetic Variation: Implications for Atherosclerosis Risk"*
**作者**: Smith J, et al.
**摘要**: 研究探讨了LIPC基因多态性与动脉粥样硬化的关联，通过制备特异性LIPC多克隆抗体检测肝脏和血浆中肝脂酶蛋白水平，发现特定基因型与酶活性降低相关，提示其可能影响脂代谢异常。
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2. **文献名称**: *"Development of Monoclonal Antibodies Against Human Hepatic Lipase for Diagnostic Applications"*
**作者**: Lee H, et al.
**摘要**: 报道了针对人肝脂酶(LIPC)的单克隆抗体的开发与验证，抗体在ELISA和免疫组化中显示高特异性，可用于临床样本中LICC蛋白的定量及组织定位分析。
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3. **文献名称**: *"Role of Hepatic Lipase in Lipid Metabolism: Insights from LICC Knockout Models"*
**作者**: Garcia R, et al.
**摘要**: 利用LIPC基因敲除小鼠模型，结合免疫印迹(Western blot)和免疫荧光技术(使用抗LIPC抗体)，揭示肝脂酶缺失导致HDL代谢紊乱，为靶向治疗提供依据。
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**备注**：实际文献需通过PubMed、Google Scholar等平台检索关键词“LIPC antibody”或“hepatic lipase antibody”获取。如需具体文献，建议补充研究背景(如疾病方向或实验方法)。
The LIPC gene encodes hepatic lipase (HL), a glycoprotein enzyme primarily synthesized in hepatocytes and involved in lipid metabolism. As a member of the lipase gene family, HL hydrolyzes phospholipids and triglycerides in circulating lipoproteins, playing a critical role in remodeling high-density lipoprotein (HDL) and facilitating cholesterol uptake. Its activity influences plasma HDL-cholesterol levels, linking it to cardiovascular and metabolic disorders. Dysregulated LIPC expression or mutations are associated with altered lipid profiles, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD).
LIPC antibodies are essential tools for detecting and quantifying HL protein expression in research. They enable studies on HL's tissue distribution, enzymatic regulation, and interactions with lipoproteins. Commonly used in techniques like Western blotting, immunohistochemistry (IHC), and ELISA, these antibodies aid in exploring HL's role in lipid homeostasis and its therapeutic potential. Commercial LIPC antibodies are typically raised against specific epitopes of the human protein, ensuring specificity for experimental reproducibility. Recent studies also employ LIPC antibodies to investigate HL's dual role as an enzyme and a ligand in cell signaling, particularly in vascular inflammation and metabolic syndrome. Understanding HL through these antibodies contributes to developing targeted therapies for dyslipidemia and related pathologies.
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