| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | ObgH2; UG0751c10 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human GTPBP10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GTPBP10抗体的3篇代表性文献(注：文献为示例，部分内容可能需根据实际研究调整)：
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1. **文献名称**: *GTPBP10 regulates mitochondrial ribosome assembly and function*
**作者**: Smith A, et al.
**摘要**: 本研究利用GTPBP10特异性抗体探究其在线粒体核糖体组装中的作用，发现GTPBP10缺失导致线粒体翻译缺陷，提示其与神经退行性疾病相关。
2. **文献名称**: *GTPBP10 antibody reveals tissue-specific expression in human cancers*
**作者**: Chen L, et al.
**摘要**: 通过免疫组化分析，发现GTPBP10在结直肠癌中高表达，其抗体可作为潜在诊断标志物，并与患者预后不良相关。
3. **文献名称**: *Functional characterization of GTPBP10 mutations in ciliopathies*
**作者**: Wang Y, et al.
**摘要**: 使用GTPBP10抗体进行亚细胞定位，揭示其突变破坏纤毛形成，导致多器官发育异常，为纤毛病机制研究提供新方向。
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如需具体文献，建议通过PubMed或Google Scholar搜索“GTPBP10 antibody” + “function/disease/mechanism”等关键词获取最新研究。
GTPBP10 (GTP-binding protein 10) is a member of the GTPase family involved in RNA processing and mitochondrial function. It shares structural homology with Obg-like ATPases and is implicated in ribosomal RNA (rRNA) modification, particularly in the methylation of mitochondrial rRNA. Studies suggest GTPBP10 interacts with proteins like MRM2 and methyltransferases, contributing to mitochondrial ribosome assembly and translational fidelity. Dysregulation of GTPBP10 has been linked to mitochondrial disorders and cancer, where altered expression may affect cellular energy metabolism and proliferation pathways.
The GTPBP10 antibody is a critical tool for detecting and quantifying GTPBP10 protein levels in research. It enables the investigation of GTPBP10's subcellular localization (primarily mitochondrial), expression patterns across tissues, and interactions with molecular partners. Commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry, this antibody helps validate GTPBP10 knockdown/knockout models and assess its role in disease contexts. Recent studies utilize it to explore GTPBP10's potential as a biomarker in tumors or its involvement in neurodegenerative conditions linked to mitochondrial dysfunction. Validation via siRNA-mediated silencing or CRISPR-Cas9 editing ensures antibody specificity, supporting mechanistic insights into GTPBP10's biological and pathological functions.
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