| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HCCR; HCCR1; HCCR2; HCCR-1; HCCR-2; HCRR-2; SLC55A3; 1110019O13Rik |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human LETMD1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于LETMD1抗体的模拟参考文献示例(请注意，以下内容为虚构，仅用于示例)：
1. **文献名称**: "LETMD1 regulates mitochondrial morphology via interaction with the fission machinery"
**作者**: Chen Y, et al.
**摘要**: 本研究利用LETMD1特异性抗体进行免疫共沉淀和免疫荧光实验，发现LETMD1通过与线粒体分裂蛋白Drp1的相互作用调控线粒体形态，缺失LETMD1导致线粒体过度碎片化，影响细胞能量代谢。
2. **文献名称**: "LETMD1 antibody-based profiling reveals its overexpression in hepatocellular carcinoma"
**作者**: Wang L, et al.
**摘要**: 通过Western blot和免疫组化分析，作者使用LETMD1抗体证实其在肝癌组织中显著高表达，且与患者预后不良相关，提示其可能作为潜在生物标志物或治疗靶点。
3. **文献名称**: "LETMD1 modulates TGF-β signaling by stabilizing SMAD4 in vascular smooth muscle cells"
**作者**: Kim S, et al.
**摘要**: 研究通过shRNA敲低和LETMD1抗体介导的蛋白质检测，发现LETMD1通过结合SMAD4抑制其泛素化降解，从而增强TGF-β信号通路，影响血管平滑肌细胞分化。
4. **文献名称**: "Developmental expression of LETMD1 in mouse embryogenesis"
**作者**: González R, et al.
**摘要**: 利用LETMD1抗体进行胚胎组织免疫染色，揭示了该蛋白在早期神经管和心脏发育中的动态表达模式，提示其在胚胎形态发生中的潜在作用。
---
**备注**：以上文献为模拟生成，实际文献需通过PubMed、Google Scholar等平台以关键词"LETMD1 antibody"或"LETMD1 protein function"检索。若需真实文献，建议结合具体研究领域进一步筛选。
**Background of LETMD1 Antibody**
The LETMD1 (LEM domain-containing protein 1) antibody is a research tool designed to detect and study the LETMD1 protein, a conserved eukaryotic protein implicated in maintaining cellular organelle morphology and function. LETMD1 is structurally characterized by a LEM (LAP2. emerin, MAN1) domain, which is known to mediate interactions with chromatin and nuclear envelope components. It localizes predominantly to the inner nuclear membrane and mitochondria, suggesting roles in nuclear organization, mitochondrial dynamics, and cellular energy metabolism.
Studies indicate that LETMD1 is critical for mitochondrial cristae structure maintenance and oxidative phosphorylation, linking it to cellular respiration and apoptosis regulation. Dysregulation of LETMD1 has been associated with pathological conditions, including cancer, neurodegenerative diseases, and metabolic disorders, highlighting its potential as a therapeutic or diagnostic target.
The LETMD1 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein expression, subcellular localization, and interactions in various experimental models. Its development and validation have enabled deeper exploration of LETMD1's molecular mechanisms, particularly in stress responses, mitochondrial dysfunction, and cell proliferation pathways. Ongoing research aims to clarify its tissue-specific functions and role in disease progression, underscoring its importance in cell biology and translational medicine.
×
