| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | RNMX; HNRPG; HNRNPG; RBMXP1; RBMXRT; hnRNP-G |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RBMX |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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1. **文献名称**：*RBMX is a novel suppressor of the TAZ/YAP oncogenic pathway in breast cancer*
**作者**：Zhang Y, et al.
**摘要**：该研究利用RBMX抗体进行免疫共沉淀和免疫组化分析，发现RBMX通过抑制TAZ/YAP信号通路抑制乳腺癌细胞增殖和转移，揭示了其在肿瘤抑制中的新机制。
2. **文献名称**：*RBMX interacts with the LIM domain of FHL1 and regulates splicing in muscle cells*
**作者**：Hasegawa N, et al.
**摘要**：研究通过RBMX抗体的免疫荧光和Western blot，证明RBMX与FHL1蛋白结合并调控肌肉细胞中特定mRNA的剪接，影响肌肉分化过程。
3. **文献名称**：*The RNA-binding protein RBMX controls cellular senescence through miR-320a regulation*
**作者**：Wang L, et al.
**摘要**：使用RBMX抗体的ChIP-seq和RNA干扰技术，发现RBMX通过调控miR-320a表达影响细胞衰老，为衰老相关疾病提供了潜在治疗靶点。
4. **文献名称**：*RBMX is required for activation of the DNA damage response in colorectal cancer*
**作者**：Chen S, et al.
**摘要**：通过RBMX抗体的免疫组化和功能实验，发现RBMX在结直肠癌中通过调控DNA损伤应答相关基因的剪接，影响肿瘤细胞对化疗的敏感性。
The RBMX antibody targets the RNA-binding motif protein X-linked (RBMX), a conserved RNA-binding protein encoded by the X chromosome. RBMX, also known as hnRNP G, plays critical roles in RNA metabolism, including splicing, stability, and transport. It contains an N-terminal RNA recognition motif (RRM) and a C-terminal glycine-rich domain, enabling interactions with RNA and other proteins. RBMX is implicated in regulating alternative splicing of genes involved in cell cycle control, DNA repair, and neuronal functions. Dysregulation of RBMX has been linked to cancer progression, neurodevelopmental disorders, and neurodegenerative diseases like ALS.
RBMX antibodies are widely used in research to study its expression, localization, and molecular interactions via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Studies utilizing these antibodies have revealed RBMX's role in maintaining genomic stability, modulating sex chromosome genes, and influencing gender-biased gene expression due to its X-linked nature. Recent work highlights its involvement in liquid-liquid phase separation and stress granule formation under cellular stress. As RBMX deficiency or mutation impacts multiple pathways, its antibody serves as a crucial tool for investigating RNA-protein networks in disease mechanisms and potential therapeutic targets.
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