| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZNF502 |
| Uniprot No | Q8TBZ5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-544 aa |
| 活性数据 | MLNMQGAEERDIRRETCPGWVNKNKPALEQDVCKIDSSGIVVKRFQEDEYQDSTFEEKYACEGMKENSPREIAESCLFQEGGFGRITFIHKEAPPEIISQGYNFEKSLLLTSSLVTRLRVSTEESLHQWETSNIQTNDISDQSKCPTLCTQKKSWKCNECGKTFTQSSSLTQHQRTHTGERPYTCEECGKAFSRSSFLVQHQRIHTGVKPYGCEQCGKTFRCRSFLTQHQRIHTGEKPYKCNECGNSFRNHSHLTEHQRIHTGEKPYKCNRCGKAFNQNTHLIHHQRIHTGEKPYICSECGSSFRKHSNLTQHQRIHTGEKPHKCDECGKTFQTKANLSQHQRIHSGEKPYKCKECGKAFCQSPSLIKHQRIHTGEKPYKCKECGKAFTQSTPLTKHQRIHTGERPYKCSECGKAFIQSICLIRHQRSHTGEKPYKCNECGKGFNQNTCLTQHMRIHTGEKPYKCKECGKAFAHSSSLTEHHRTHTGEKLYKCSECEKTFRKYAHLSEHYRIHTGEKPYECIECGKFFRHSSVLFRHQKLHSGD |
| 分子量 | 89.3 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZNF502蛋白的虚构参考文献示例，供参考：
1. **文献名称**：*Cloning and Functional Analysis of Human ZNF502 in Transcriptional Regulation*
**作者**：Chen L, Wang Y, et al.
**摘要**：研究报道了ZNF502基因的克隆及其重组蛋白在HEK293细胞中的表达与纯化，发现ZNF502通过结合特定DNA序列抑制促炎因子基因(如IL-6)的转录，提示其在炎症调控中的作用。
2. **文献名称**：*ZNF502 Protein Promotes Tumor Apoptosis via p53 Signaling Pathway*
**作者**：Smith J, Rodriguez M, et al.
**摘要**：通过体外实验表明，重组ZNF502蛋白能增强p53依赖的凋亡通路，在肺癌细胞系中诱导 caspase-3活化，提示其作为潜在肿瘤治疗靶点。
3. **文献名称**：*Structural Characterization of ZNF502 and Its Interaction with Chromatin*
**作者**：Kim S, Patel R, et al.
**摘要**：利用X射线晶体学解析了ZNF502的锌指结构域，揭示其与染色质结合的分子机制，为理解其在表观遗传调控中的功能提供结构基础。
4. **文献名称**：*Dysregulation of ZNF502 in Neurodegenerative Disorders*
**作者**：Zhang H, et al.
**摘要**：发现ZNF502在阿尔茨海默病患者脑组织中表达下调，动物模型显示过表达重组ZNF502可缓解神经元损伤，可能与调控氧化应激相关基因有关。
**注意**：以上文献为模拟示例，实际引用请通过PubMed、Google Scholar等平台检索真实论文。
ZNF502. a member of the zinc finger protein (ZFP) family, is characterized by conserved Cys₂His₂ (C2H2)-type zinc finger domains, which mediate sequence-specific DNA binding and play critical roles in transcriptional regulation. As a transcription factor, ZNF502 is hypothesized to participate in diverse cellular processes, including cell differentiation, proliferation, and apoptosis, though its precise biological functions remain less characterized compared to other ZFPs. The protein is encoded by the ZNF502 gene located on human chromosome 19. and its expression is detected across various tissues, suggesting potential tissue-specific regulatory roles.
Recombinant human ZNF502 protein is engineered using molecular cloning techniques, typically expressed in heterologous systems (e.g., *E. coli* or mammalian cells) to ensure proper folding and post-translational modifications. This recombinant form enables functional studies, such as elucidating DNA-binding specificity, protein-protein interactions, and pathways influenced by ZNF502. Current research highlights its possible involvement in neurodevelopment and cancer, with dysregulation observed in certain tumors and neurological disorders. However, mechanistic insights remain limited, necessitating further investigation into its target genes and regulatory networks. Recombinant ZNF502 also serves as a tool for drug screening or antibody development, aiding therapeutic strategies aimed at ZFP-related diseases. Its study contributes to understanding the broader functional diversity of zinc finger proteins in health and disease.
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