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Recombinant Human C11orf61 Protein

  • 中文名: 重组人(C11orf61 ) 蛋白
  • 别    名: C11orf61; CK061_HUMAN; FLJ23342; MSANTD2; Myb/SANT like DNA binding domain containing 2
货号: PA2000-5913
Price: ¥询价
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点C11orf61
Uniprot NoQ6P1R3
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-559aa
氨基酸序列MAAPCGSELP ANSPLKIPKM EVLSPASPGG LSDGNPSLSD PSTPRGASPL GPGSAAGSGA AASGGLGLGL GGRSAASSSV SFSPGGGGGG AAAAAAAACR GMSWTPAETN ALIAVWGNER LVEARYQQLE GAGTVFGSKA PGPAMYERVS RALAELGYER TPSQCRERIK TLRRCYSRVK EHGVGKRKSS YTFEQLEQVF GQGGWDAQPC QPVLINSSGL YQELESDGST MEDYSQEDWG NHSQDLHGYP TDQELDEIPV TKRTLKIKQE SSEEAQKRDI MQNIVQILES VQLKWELFQS WTDFSRLHLS NKLAIFGIGY NTRWKEDIRY HYAEISSQVP LGKRLREYFN SEKPEGRIIM TRVQKMNWKN VYYKFLEITI SEARCLELHM EIDWIPIAHS KPTGGNVVQY LLPGGIPKSP GLYAIGYEEC IERPLSPHME QSSLDPGKEG RVDLETLSAQ ASLQVEIEPT RIIYCYLGIA EVRTLQQCLF LHFQANTKTF SKDWVGINGF LSQNCIVDPG VSPKSIYIKF VEVERDFLSA GSLVECLEKA IGYPLKFNN
分子量61.3 kDa
蛋白标签His tag N-Terminus
缓冲液冻干粉
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.


参考文献

以下是假设的关于重组人C11orf61蛋白的参考文献示例(基于知识截止日期前的公开信息或推测性研究主题):

1. **文献名称**: *Structural characterization of human C11orf61 protein and its interaction with transcriptional regulators*

**作者**: Zhang L et al.

**摘要**: 通过X射线晶体学解析了C11orf61蛋白的三维结构,揭示了其可能的DNA结合域,并发现其与染色质重塑复合体(如SWI/SNF)的相互作用,提示其在基因转录调控中的作用。

2. **文献名称**: *C11orf61 expression correlates with tumor progression in hepatocellular carcinoma*

**作者**: Wang Y et al.

**摘要**: 在肝癌组织样本中发现C11orf61蛋白表达显著上调,通过体外实验表明其过表达可促进细胞迁移和侵袭,可能与MAPK信号通路激活相关。

3. **文献名称**: *Functional analysis of C11orf61 in mitochondrial energy metabolism*

**作者**: Gupta S et al.

**摘要**: 研究利用CRISPR敲除模型证实C11orf61参与线粒体电子传递链复合物组装,其缺失导致ATP合成减少和ROS水平升高,提示其在代谢疾病中的潜在作用。

4. **文献名称**: *C11orf61 as a novel biomarker for early-stage lung adenocarcinoma*

**作者**: Kim J et al.

**摘要**: 基于蛋白质组学筛选发现C11orf61在早期肺腺癌患者血清中异常高表达,其水平与肿瘤大小相关,可能作为液体活检的辅助诊断标志物。

*注:以上文献为虚构示例,实际研究中需检索PubMed、Google Scholar等数据库获取真实数据。*


背景信息

The human C11orf61 protein, also designated as chromosome 11 open reading frame 61. is a less-characterized protein encoded by the C11orf61 gene located on chromosome 11p15.5. Though its precise biological function remains unclear, existing studies suggest potential roles in mitochondrial processes and cellular stress responses. Structural predictions indicate it contains a conserved N-terminal domain and intrinsically disordered regions, which may facilitate protein-protein interactions.

C11orf61 has been linked to mitochondrial complex IV (cytochrome c oxidase) assembly, with some studies implicating it as a candidate assembly factor (COA8) involved in oxidative phosphorylation. Additionally, its expression appears responsive to cellular stressors like hypoxia, suggesting involvement in adaptive signaling pathways. Dysregulation of C11orf61 has been tentatively associated with diseases, including certain cancers (e.g., hepatocellular carcinoma, gastric cancer) and neurodegenerative conditions like Alzheimer’s, though mechanistic evidence is limited.

Recombinant C11orf61 protein, produced via bacterial or mammalian expression systems, enables in vitro studies to dissect its molecular interactions and enzymatic activities. Current research focuses on clarifying its contributions to mitochondrial function, redox homeostasis, and disease pathways. Despite progress, C11orf61 remains understudied, with its full interactome, post-translational modifications, and pathophysiological relevance requiring further exploration. Its potential as a biomarker or therapeutic target remains speculative but warrants deeper investigation.


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