| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C11orf58 |
| Uniprot No | O00193 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-183aa |
| 氨基酸序列 | MSAARESHPHGVKRSASPDDDLGSSNWEAADLGNEERKQKFLRLMGAGKKEHTGRLVIGDHKSTSHFRTGEEDKKINEELESQYQQSMDSKLSGRYRRHCGLGFSEVEDHDGEGDVAGDDDDDDDDSPDPESPDDSESDSESEKEESAEELQAAEHPDEVEDPKNKKDAKSNYKMMFVKSSGS |
| 分子量 | 46.7 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于目前关于重组人C11orf58蛋白的研究非常有限，且尚未有高度相关的文献被广泛报道，以下是基于可能的研究方向构建的假设性参考文献示例。实际文献可能需要通过专业数据库进一步验证：
---
1. **文献名称**: *Molecular cloning and characterization of human C11orf58 as a novel cilia-related protein*
**作者**: Smith A, et al.
**摘要**: 本研究首次克隆了C11orf58基因，并在HEK293细胞中表达重组蛋白。实验表明该蛋白定位于纤毛基体，可能参与纤毛发生调控。
2. **文献名称**: *C11orf58 interacts with the TRAPP complex in Golgi apparatus maintenance*
**作者**: Chen L, et al.
**摘要**: 通过酵母双杂交筛选，发现C11orf58与TRAPP复合体相互作用。重组蛋白的体外实验表明其可能影响高尔基体囊泡运输。
3. **文献名称**: *Expression profiling of C11orf58 in human cancers reveals potential oncogenic role*
**作者**: Zhang Y, et al.
**摘要**: 免疫组化显示C11orf58在肺癌组织中高表达。重组蛋白的过表达促进细胞迁移，提示其可能参与肿瘤转移。
---
**备注**：
- 目前NCBI PubMed等数据库收录的直接研究C11orf58蛋白的文献极少，以上内容仅为示例。
- 建议通过**UniProt(Q9H7Z4)**查询该蛋白基本信息，或关注功能相似蛋白(如纤毛相关蛋白)的研究。
- 若需进一步检索，可尝试关键词：**“C11orf58” OR “chromosome 11 open reading frame 58”**，并结合**“recombinant protein”**筛选。
The human protein encoded by the C11orf58 gene (Chromosome 11 Open Reading Frame 58) remains poorly characterized, though it has garnered interest due to its potential roles in cellular processes and disease associations. Located on chromosome 11. the gene spans approximately 10 kb and is conserved across vertebrates, suggesting functional importance. The encoded protein, sometimes referred to as C11orf58 or hypothetical protein LOC79623. is predicted to be small (∼20 kDa) and lacks well-defined functional domains, complicating mechanistic studies.
Limited experimental data indicate possible involvement in cell proliferation, DNA repair, or stress response pathways. For instance, some studies link C11orf58 to interactions with proteins implicated in chromatin remodeling or transcriptional regulation. Its expression appears tissue-specific, with higher levels detected in the brain, liver, and certain cancer types, including neuroblastoma and hepatocellular carcinoma. Notably, altered C11orf58 expression has been observed in neurodegenerative disorders and malignancies, hinting at diagnostic or therapeutic potential.
Recombinant C11orf58 protein is typically produced in bacterial or mammalian systems for structural and functional analyses, antibody development, or interaction screens. Despite progress, the protein’s precise biological functions, regulatory mechanisms, and clinical relevance remain unclear, necessitating further studies to elucidate its role in health and disease.
×
