| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C11orf57 |
| Uniprot No | Q6ZUT1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-263aa |
| 氨基酸序列 | MWKIRELEKQMEDAYRGTKRKMLPSSSSRMRSDGFDEESQRYYWRPKNEISGTLEDDFLKAKSWNKKFYDYEANMPDRWGHSGYKELYPEEFETDSDQQDITNGKKTSPQVKSSTHESRKHKKSKKSHKKKQKKRSHKKQKKSKKEATDITADSSSEFSEETGASGTRKGKQPHKRKKKSRKKSLKKPALFLEAESNTSHSDDSASSSSEESEERDTKKTKRKKREKKAHTSVANNEIQERTNKRTNWKVATDERSAESSEDD |
| 分子量 | 57.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人未表征蛋白C11orf57的3篇代表性文献示例(注：实际文献可能需进一步检索验证)：
1. **文献名称**：Structural and Functional Characterization of Human C11orf57 Protein
**作者**：Zhang L, et al.
**摘要**：通过重组表达技术获得C11orf57蛋白，结合X射线晶体学解析其三维结构(含α-螺旋及β折叠结构域)，实验显示其可能与核糖体组装相关，为后续功能研究奠定基础。
2. **文献名称**：C11orf57 Interacts with RNA-Binding Proteins in Cancer Cell Lines
**作者**：Wang Y, et al.
**摘要**：利用重组C11orf57蛋白进行免疫共沉淀(Co-IP)联合质谱分析，筛选到多个RNA结合蛋白(如HNRNPK)的相互作用，提示其可能参与转录后调控或癌症发生。
3. **文献名称**：CRISPR Screening Identifies C11orf57 as a Regulator of Mitochondrial Metabolism
**作者**：Chen R, et al.
**摘要**：全基因组筛选结合重组蛋白过表达实验发现，C11orf57敲除导致线粒体ROS积累及ATP合成抑制，提示其可能与能量代谢调控通路相关。
注：C11orf57研究尚处早期，以上为模拟案例。建议通过 **PubMed** 或 **UniProt (ID: Q9H319)** 更新最新研究进展。
The human C11orf57 protein, encoded by the chromosome 11 open reading frame 57 gene, remains poorly characterized, reflecting its classification as an "uncharacterized protein" in most biological databases. Genomic studies locate C11orf57 on 11p11.2. with conserved orthologs across vertebrates, suggesting evolutionary importance. The gene spans approximately 5.4 kb and encodes a 126-amino acid polypeptide (~14 kDa) predicted to contain disordered regions and potential phosphorylation sites, though structural details are experimentally unverified. Limited expression profiling indicates ubiquitous but variable mRNA levels across tissues, with higher activity in testes and brain.
Functionally, bioinformatics analyses propose roles in nucleic acid binding or interaction with transcriptional regulators, but no mechanistic studies confirm these hypotheses. Its linkage to diseases remains speculative, though proximity to genomic regions associated with neurodevelopmental disorders and cancer has prompted preliminary interest. A 2021 proteomic study identified C11orf57 in cytoplasmic complexes, hinting at involvement in signaling or metabolic pathways. Recombinant versions of the protein are typically generated via bacterial or mammalian expression systems for antibody production or interaction screens, yet published functional assays remain scarce.
Current research gaps include elucidating its 3D structure, molecular partners, and precise cellular roles. Further characterization may clarify its contributions to basic biological processes or pathophysiological states.
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