| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C11orf48 |
| Uniprot No | Q9BQE6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-263aa |
| 氨基酸序列 | MALVPGRSKEDGLWTRNSPGSSQHPESPRLPNPLWDRGKIGKVEGHQHIQDFSQKSHLPSIVVESSEVNEESGDLHLPHEELLLLTDGEEEDAEAFFQDQSEEPGWAWSPQDPRSPLRTFNAGLSWGQDQDEEDACWILEDTACLEATNHCPFWDSTGSRVCRSGFVEYSHLLPPNSFEGAEEEAVQTPAGVESGAASEAPGGRGCDRPRADHAAPPQEAGVQCTCQHYTVREEAQKTPPADPACPEREDSHGSGSPFKASQD |
| 分子量 | 55.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C11orf48蛋白的参考文献示例(注：以下为假设性示例，实际文献需通过学术数据库获取)：
1. **文献名称**：*C11orf48 interacts with HSP90 to promote cancer cell proliferation*
**作者**：Smith A, et al.
**摘要**：研究揭示了重组人C11orf48蛋白通过结合分子伴侣HSP90.增强其客户蛋白的稳定性，促进癌细胞增殖和肿瘤生长。
2. **文献名称**：*Structural characterization and functional analysis of human C11orf48*
**作者**：Lee B, et al.
**摘要**：通过重组表达纯化C11orf48蛋白，解析其晶体结构，并证明其在细胞周期调控中的潜在作用，可能与DNA损伤修复通路相关。
3. **文献名称**：*C11orf48 as a novel regulator of ribosome biogenesis*
**作者**：Garcia C, et al.
**摘要**：研究发现重组C11orf48蛋白在核仁中富集，通过与核糖体RNA加工因子的相互作用，影响核糖体组装及蛋白质合成效率。
4. **文献名称**：*C11orf48 knockdown impairs mitochondrial function via metabolic reprogramming*
**作者**：Wang X, et al.
**摘要**：利用重组蛋白及基因编辑技术，证明C11orf48通过调控线粒体代谢酶活性，维持细胞能量稳态，其缺失导致氧化磷酸化异常。
**建议**：实际研究中，可通过PubMed、Google Scholar等平台检索最新文献，关键词建议组合使用(如“C11orf48”、“recombinant protein”、“function”或“mechanism”)。部分研究可能以“C11orf48”的别名(如HJURP2等)发表，需注意名称变更。
The human C11orf48 protein, encoded by the *C11orf48* gene on chromosome 11 (11q13.1), remains poorly characterized, though it is implicated in cellular processes like proliferation, differentiation, and stress response. Initially identified through genomic sequencing, it is a small protein (∼20 kDa) with conserved regions suggesting possible roles in protein-protein or nucleic acid interactions. Bioinformatic analyses predict nuclear or cytoplasmic localization, aligning with studies linking it to transcriptional regulation or RNA metabolism.
While its precise molecular function is unclear, C11orf48 has been associated with cancers (e.g., hepatocellular carcinoma, breast cancer) and neurological disorders, potentially acting as an oncogene or tumor suppressor depending on context. Elevated expression in certain tumors correlates with poor prognosis, hinting at clinical relevance.
Recombinant C11orf48 protein, typically produced in *E. coli* or mammalian systems, enables functional studies, antibody development, and structural analysis. Challenges include low endogenous expression and lack of specific inhibitors/antibodies. Ongoing research focuses on elucidating its interactome, post-translational modifications, and therapeutic potential. Further investigation is needed to define its biological roles and mechanisms in health and disease.
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