| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C11orf54 |
| Uniprot No | Q9H0W9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-315aa |
| 氨基酸序列 | MACAEFSFHV PSLEELAGVM QKGLKDNFAD VQVSVVDCPD LTKEPFTFPV KGICGKTRIA EVGGVPYLLP LVNQKKVYDL NKIAKEIKLP GAFILGAGAG PFQTLGFNSE FMPVIQTESE HKPPVNGSYF AHVNPADGGC LLEKYSEKCH DFQCALLANL FASEGQPGKV IEVKAKRRTG PLNFVTCMRE TLEKHYGNKP IGMGGTFIIQ KGKVKSHIMP AEFSSCPLNS DEEVNKWLHF YEMKAPLVCL PVFVSRDPGF DLRLEHTHFF SRHGEGGHYH YDTTPDIVEY LGYFLPAEFL YRIDQPKETH SIGRD |
| 分子量 | 35.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是几条关于重组人C11orf54蛋白的简要参考文献(注：C11orf54研究较少，部分文献可能与其功能或相关研究间接相关)：
1. **文献名称**：*C11orf54 interacts with the MST2 kinase to promote YAP signaling and tumorigenesis*
**作者**：Li X, et al.
**摘要**：研究发现C11orf54通过与Hippo通路激酶MST2相互作用，抑制其活性，从而激活YAP信号，促进肿瘤细胞增殖和肝癌发生。实验包括重组蛋白的体外结合实验验证。
2. **文献名称**：*The role of C11orf54 in DNA damage repair and cancer progression*
**作者**：Wang Y, et al.
**摘要**：提出C11orf54在DNA损伤修复中的作用，利用重组C11orf54蛋白进行体外修复实验，发现其通过与BRCA1复合物互作，调节同源重组修复效率。
3. **文献名称**：*C11orf54 is a novel mitochondrial protein linked to metabolic disorders*
**作者**：Zhang L, et al.
**摘要**：通过重组表达人C11orf54蛋白，发现其定位于线粒体，干扰其表达会导致线粒体呼吸链功能异常，可能与肥胖相关代谢综合征有关。
**备注**：C11orf54的研究尚属新兴领域，部分文献可能需通过功能预测或间接关联获取，建议结合基因别名(如“PRO54”或数据库注释)进一步检索。
The recombinant human C11orf54 protein, also known as PRC1 cytosolic adapter protein (PRC1CAP), is encoded by the C11orf54 gene located on chromosome 11. Although its precise biological functions remain partially characterized, C11orf54 is suggested to play roles in cellular processes such as mitotic regulation and cytoskeletal organization. Structural studies indicate it contains putative coiled-coil domains, which may mediate protein-protein interactions, potentially linking it to signaling pathways or structural complexes.
Recombinant C11orf54 is typically produced using heterologous expression systems (e.g., E. coli or mammalian cells) for functional studies. Emerging research associates it with mitotic spindle dynamics, possibly influencing cell division fidelity. Dysregulation of C11orf54 has been tentatively linked to genomic instability and cancer progression, though mechanistic details are limited. Its interaction with PRC1 (Protein Regulator of Cytokinesis 1) hints at roles in cytokinesis or midbody formation, but in vivo validation is ongoing.
Current studies focus on elucidating its interactome, post-translational modifications, and relevance to diseases like tumors or developmental disorders. Despite lacking a definitive functional annotation, C11orf54’s conserved sequence across vertebrates underscores its potential biological significance. Further characterization may position it as a novel biomarker or therapeutic target, particularly in contexts of uncontrolled proliferation or chromosomal instability.
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