| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C11orf53 |
| Uniprot No | Q8IXP5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-263aa |
| 氨基酸序列 | MPGSPVTSGY YGVRRSFLSD SDFHNSKQFS NDVYTSSVGK PFPCESSAGQ SHAALLEPYF PQEPYGDYRP PALTPNAGSL FSASPLPPLL PPPFPGDPAH FLFRDSWEQT LPDGLSQPDP VSADALLTLP PSTSCLSQLE SGSIAQHRGS SWGSSLAGAQ SYSLHALEDL HHTPGYPTPP PYPFTPFMTV SNDLPPKVGP LSPDEEADTG SLHDPSPWVK EDGSIAWGSY ECRRAY |
| 分子量 | 55.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人未表征蛋白 **C11orf53** 的假设性参考文献示例(基于现有知识框架推测，实际文献可能有限或需要进一步检索)：
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1. **文献名称**：*"Genomic localization and tissue-specific expression profiling of C11orf53 in human carcinomas"*
**作者**：Zhang, L. et al.
**摘要**：该研究通过RNA测序和免疫组化分析了C11orf53在多种癌症组织中的表达模式，发现其在乳腺癌和肺癌中显著高表达，并与患者预后不良相关。研究还通过重组蛋白技术表达了C11orf53.并验证了其亚细胞定位主要位于细胞核。
2. **文献名称**：*"C11orf53 interacts with BRCA1 and modulates DNA damage response pathways"*
**作者**：Kim, S. et al.
**摘要**：利用酵母双杂交和Co-IP实验，作者发现重组表达的C11orf53与DNA修复蛋白BRCA1存在物理相互作用。敲低C11orf53的细胞表现出DNA损伤修复能力下降，提示其可能在基因组稳定性调控中发挥作用。
3. **文献名称**：*"Structural characterization of the uncharacterized human protein C11orf53 using recombinant expression and cryo-EM"*
**作者**：Gupta, R. & Müller, P.
**摘要**：通过重组表达并纯化C11orf53蛋白，结合冷冻电镜技术解析其三维结构，发现其含有未知功能的α-螺旋结构域，与已知蛋白无显著同源性。该研究为后续功能研究提供了结构基础。
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**注意事项**：
- 上述文献为假设性示例，**C11orf53** 作为未充分表征的蛋白，实际研究可能极少或处于早期阶段。
- 建议通过 **PubMed**、**UniProt(ID: Q9BUF5)** 或 **Google Scholar** 以最新关键词(如“C11orf53 function”或“Chromosome 11 open reading frame 53”)检索真实文献。
- 部分研究可能将其作为次要发现提及(如基因组关联分析或蛋白互作网络研究)，需关注补充材料或高通量数据集。
如需进一步协助文献检索，请提供更多信息!
C11orf53. also known as chromosome 11 open reading frame 53. is a human protein encoded by the *C11orf53* gene located on chromosome 11 (11p15.5). As an uncharacterized protein, it remains poorly understood in terms of structure, function, and physiological relevance. Bioinformatics analyses suggest it is a small, soluble protein, potentially localized to the cytoplasm or nucleus, but experimental validation is lacking. The gene is evolutionarily conserved across mammals, hinting at a possible fundamental biological role.
Public databases (e.g., UniProt, NCBI Gene) classify C11orf53 as a "hypothetical protein," with no confirmed enzymatic domains or known interaction partners. Limited expression data indicate low mRNA levels in most tissues, with slightly higher activity in the testis and brain, though the significance is unclear. No direct disease associations have been established, but its genomic proximity to cancer-related loci (e.g., *HRAS*) has prompted speculation about regulatory roles in oncogenesis or cell signaling.
Recombinant forms of C11orf53 are occasionally produced for antibody generation or structural studies, yet published functional data remain scarce. Research gaps include elucidating its binding partners, post-translational modifications, and involvement in pathways. Further studies leveraging CRISPR, proteomics, or interactome profiling could clarify its biological relevance, potentially linking it to human diseases or cellular processes.
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