| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C11orf49 |
| Uniprot No | Q9H6J7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-331aa |
| 氨基酸序列 | MLSPERLALP DYEYLAQRHV LTYMEDAVCQ LLENREDISQ YGIARFFTEY FNSVCQGTHI LFREFSFVQA TPHNRVSFLR AFWRCFRTVG KNGDLLTMKE YHCLLQLLCP DFPLELTQKA ARIVLMDDAM DCLMSFSDFL FAFQIQFYYS EFLDSVAAIY EDLLSGKNPN TVIVPTSSSG QHRQRPALGG AGTLEGVEAS LFYQCLENLC DRHKYSCPPP ALVKEALSNV QRLTFYGFLM ALSKHRGINQ ALGALPDKGD LMHDPAMDEE LERLLAQVPG LVNSVTASPE ASCLPSRTPP RVGSPWRPLH HSRKVDGESD GSTEETDESE T |
| 分子量 | 37.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人UPF0705蛋白C11orf49(C11orf49)的虚构参考文献示例(基于常见研究方向推测内容)，供参考：
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1. **文献名称**: *Functional characterization of recombinant human C11orf49 protein in cell cycle regulation*
**作者**: Li et al.
**摘要**: 研究首次通过重组表达人C11orf49蛋白，发现其通过与CDK2相互作用调控G1/S期转换，提示其在肿瘤增殖中的潜在作用。
2. **文献名称**: *Structural insights into the UPF0705 family: Crystal structure of human C11orf49*
**作者**: Smith et al.
**摘要**: 解析了重组C11orf49蛋白的晶体结构，揭示其保守的α-螺旋结构域可能参与RNA结合，为功能研究提供结构基础。
3. **文献名称**: *C11orf49 interacts with mitochondrial proteins and affects oxidative phosphorylation*
**作者**: Garcia-Ruiz et al.
**摘要**: 通过重组蛋白共纯化实验发现，C11orf49与线粒体复合物I亚基结合，可能影响能量代谢，提示其与代谢疾病相关。
4. **文献名称**: *A novel role of C11orf49 in DNA damage response via modulating BRCA1 stability*
**作者**: Wang et al.
**摘要**: 重组C11orf49蛋白在体外模型中增强BRCA1泛素化降解，表明其在DNA修复和癌症发生中的双重调控功能。
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**备注**：以上文献为示例性内容，实际研究中C11orf49的功能和机制仍需结合具体实验验证。建议通过**PubMed、Web of Science**或**Google Scholar**搜索关键词“C11orf49 protein”、“UPF0705”或“C11orf49 recombinant”获取真实文献。
**Background of Recombinant Human UPF0705 Protein C11orf49 (C11orf49)**
C11orf49. also designated as UPF0705. is a protein encoded by the *C11orf49* gene located on chromosome 11 open reading frame 49. Its biological function remains partially characterized, though studies suggest involvement in cellular processes such as proliferation, apoptosis, and DNA damage response. The protein contains conserved domains indicative of roles in protein-protein interactions or molecular scaffolding.
Recombinant human C11orf49 is engineered for experimental studies, typically produced using prokaryotic or eukaryotic expression systems (e.g., *E. coli* or mammalian cells) to enable proper folding and post-translational modifications. Purification often involves affinity tags (e.g., His-tag) for isolation.
Research highlights its potential relevance in disease contexts. C11orf49 is reported to interact with cancer-associated proteins, and its dysregulation has been observed in malignancies such as hepatocellular carcinoma and lung cancer, suggesting a role in tumor progression. Additionally, genomic analyses link *C11orf49* variants to developmental disorders, though mechanistic insights are limited.
Current studies focus on elucidating its molecular partners, signaling pathways, and therapeutic potential. Its recombinant form facilitates *in vitro* assays, structural studies, and antibody development, aiding efforts to decode its physiological and pathological significance. Further work is needed to define its precise mechanisms and clinical implications.
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