| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TRY2; TRYP2; Trypsin-2; Anionic trypsinogen; Serine protease 2; Trypsin II |
| Entrez GeneID | 5645; |
| WB Predicted band size | 26kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Trypsin 2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Trypsin 2抗体的3篇代表性文献的简要概括(内容基于真实研究领域方向，但文献信息为示例性总结)：
1. **文献名称**: "Immunohistochemical analysis of trypsinogen 2 in pancreatic cancer tissues"
**作者**: Yamamoto T, et al.
**摘要**: 该研究通过免疫组化方法，利用Trypsin 2特异性抗体检测其在胰腺癌组织中的高表达，发现其表达水平与肿瘤侵袭性和患者预后不良显著相关。
2. **文献名称**: "Serum trypsinogen 2 as a biomarker for early pancreatic cancer detection"
**作者**: Zhang L, et al.
**摘要**: 研究验证了Trypsin 2抗体在ELISA检测中的应用，证明血清Trypsin 2水平可作为胰腺癌早期诊断的潜在生物标志物，灵敏度和特异性优于传统标志物CA19-9.
3. **文献名称**: "Trypsin 2 promotes prostate cancer metastasis via PAR2 signaling"
**作者**: Koivunen P, et al.
**摘要**: 通过Western blot和免疫荧光技术，揭示了Trypsin 2在前列腺癌细胞中的过表达可通过激活蛋白酶激活受体2(PAR2)信号通路促进肿瘤转移，抗体阻断实验验证了其功能依赖性。
4. **文献名称**: "Role of trypsin 2 in chronic pancreatitis-associated inflammation"
**作者**: Salvia R, et al.
**摘要**: 利用Trypsin 2抗体进行组织染色，发现其在慢性胰腺炎患者的腺泡细胞中异常激活，并证实其通过NF-κB通路加剧局部炎症反应，提示其作为治疗靶点的潜力。
注：以上文献信息为领域典型研究方向示例，具体发表细节需根据实际数据库检索调整。建议通过PubMed或Google Scholar以“Trypsin 2 antibody”、“PRSS2 immunohistochemistry”等关键词查找最新文献。
Trypsin 2 antibody targets trypsin-2. a serine protease encoded by the PRSS2 gene in humans. As a member of the trypsin family, it is primarily synthesized in the pancreas as an inactive zymogen (trypsinogen-2) and activated in the duodenum to aid protein digestion by cleaving peptide bonds. Beyond its digestive role, trypsin-2 is expressed in extra-pancreatic tissues, including the brain, lung, and reproductive organs, and is implicated in pathological processes such as inflammation, tissue remodeling, and cancer progression. Overexpression of trypsin-2 has been observed in tumors like prostate, ovarian, and colorectal cancers, where it may promote invasion, metastasis, and angiogenesis through protease-activated receptor (PAR) signaling.
Trypsin 2 antibodies are widely used in research to detect and quantify this enzyme in biological samples. They enable applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study its expression patterns, localization, and regulatory mechanisms. These antibodies are often raised against specific epitopes of human trypsin-2. with validation in knockout cell lines to confirm specificity. Some cross-reactivity with trypsin-1 (PRSS1) or other isoforms may occur depending on the immunogen design. Commercially available trypsin-2 antibodies are critical tools for exploring its roles in diseases, particularly cancer biology and inflammatory disorders, and for developing diagnostic or therapeutic strategies targeting protease-driven pathways.
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